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BCL6-IN-8c Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5768585

BCL6-IN-8c is an orally active and potent inhibitor of B-cell lymphoma 6 (BCL6)-corepressor interaction(IC50 of 0.10uM in cell-free enzyme-linked immunosorbent assay). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BCL6-IN-8c, Inhibitor
Full Product Name
BCL6-IN-8c
Product Gene Name
BCL6-IN-8c, inhibitor
Purity/Purification
98%
Preparation and Storage
Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years
Molecular Weight
417.85
SMILES
[O-][N+](=O)c1cc(Cl)c(Nc2ccc3NC(=O)CCc3c2)cc1OC1CCOCC1
Formula
C20H20ClN3O5
CAS Number
2130878-25-8
Target
Others
B-cell lymphoma 6 BCL6-corepressor interaction: 0.10uM
Solubility
(<1mg/mL refers to the product slightly soluble or insoluble)
In_vitro
BCL6-IN-8c exhibits a good pharmacokinetic profile (Cmax = 233ng/mL Tmax = 2hours, MRT = 3.3 h, AUC = 1.27mg/h/mL F (oral bioavailability) = 79.9%)[1]. The pharmacokinetic profile of BCL6-IN-8c (Compound 8c) is evaluated by a mouse cassette-dosing study (0.1mg/kg iv; 1mg/kg po).

Product Categories/Family for BCL6-IN-8c, inhibitor

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Structure of BCL6-IN-8c, inhibitor

BCL6-IN-8c, CAS 2130878-25-8
BCL6-IN-8c Inhibitor – Cat# MBS5768585

Structure of BCL6-IN-8c, inhibitor

BCL6-IN-8c, CAS 2130878-25-8
BCL6-IN-8c Inhibitor, Structure – Cat# MBS5768585

Product References and Citations for BCL6-IN-8c, inhibitor

1 Yasu T e al Discover o nove B-cel lymphom (BCL6)-corepresso interactio inhibito b utilizin structure-base dru design Bioor Me Chem 201 Se 1 5(17):4876-4886.

Other Notes

Small volumes of BCL6-IN-8c, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCL6-IN-8c purchase

MBS5768585 is an inhibitor targeting BCL6-IN-8c.
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