BMS-955176 Inhibitor – TFA

GSK3532795 is an orally active inhibitor of HIV-1 maturation. GSK3532795 combines broad coverage of polymorphic viruses (EC50: 15nM toward a panel of common polymorphisms representative of 96.5% HIV-1 subtype B virus) with a favorable pharmacokinetic profile in preclinical species.

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1 Orti A suumeillan M Savag SA Strotma NA Hale M Benkovic T Ny J X Z Ta Y Ayer S Ga Q Kia S Synthesi o HIV-Maturatio Inhibito BMS-95517 fro Betuli b a Enablin Oxidatio Strategy Or Chem 201 Ma 5 2(9):4958-4963 doi 10.1021/acs.joc.7b00438 Epu 201 Ap 19 PubMe PMID 28406018 href="javascript:void(0) rel="nofollow >
2 Strotma NA Orti A Savag SA Wilber CR Ayer S Kia S Revisitin Classi Transformation Losse Rearrangemen Initiate b Nitrile an "Pseudo-Catalytic i Isocyanate Or Chem 201 Ap 21 2(8):4044-4049 doi 10.1021/acs.joc.7b00450 Epu 201 Ap 12 PubMe PMID 28394130 href="javascript:void(0) rel="nofollow >
3 Li Z Canton J L H Nowicka-San B Protac T Yua T Yan H Li Z Drexle D Regueiro-Re A Meanwel NA Cocket M Krysta M Lataillad M Dicke IB Mechanisti Studie an Modelin Revea th Origi o Differentia Inhibitio o Ga Polymorphi Viruse b HIV- Maturatio Inhibitors PLo Pathog 201 No 28 2(11):e1005990 doi 10.1371/journal.ppat.1005990 eCollectio 201 Nov PubMe PMID 27893830 PubMe Centra PMCID PMC5125710 href="javascript:void(0) rel="nofollow >
4 Regueiro-Re A Li Z Che Y Si N Si SY Swidorsk JJ Che J Venable BL Zh J Nowicka-San B Protac T Li Z Terr B Samant H Zhan S L Z Ben BR Huan XS Rahematpur S Parke DD Haskel R Jenkin S Santon KS Cocket MI Krysta M Meanwel NA HauMegowd U Dicke IB Discover o BMS-955176 Secon Generatio HIV- Maturatio Inhibito wit Broa Spectu Antivira Activity AC Me Che Lett 201 Ap 22 (6):568-72 doi 10.1021/acsmedchemlett.6b00010 eCollectio 201 Ju 9 PubMe PMID 27326328 PubMe Centra PMCID PMC4904268.

Small volumes of BMS-955176, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5773573 is an inhibitor targeting BMS-955176. Also known as BMS-955176 TFA.