BSJ-4-116 Inhibitor

Name: BSJ-4-116 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5765221
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5765221

BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 . It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BSJ-4-116, Inhibitor

Full Product Name

BSJ-4-116

Product Gene Name

BSJ-4-116, inhibitor

Form/Format

Solid

Purity/Purification

0.9909

Preparation and Storage

Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).

Molecular Weight

837.38

Solubility

DMSO: 250mg/mL (298.55mM)
Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

SMILES

O=C(NCCCCCCCN1C[C@H](NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)CCC1)COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O

Formula

C40H49ClN8O8S

CAS Number

2519823-34-6

Product Categories/Family for BSJ-4-116, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for BSJ-4-116, inhibitor

Jiang B, et al. Discovery and resistance mechanism of a selective CDK12 degrader. Nat Chem Biol. 2021;17(6):675-683.

Other Notes

Small volumes of BSJ-4-116, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BSJ-4-116 purchase

MBS5765221 is an inhibitor targeting BSJ-4-116.