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CBB1007 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5766283

CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27uM for hLSD1). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CBB1007, Inhibitor
Full Product Name
CBB1007
Product Gene Name
CBB1007, inhibitor
Purity/Purification
98%
Preparation and Storage
Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years
Molecular Weight
534.621
SMILES
COC(=O)c1cc(CN2CCN(CC2)C(N)=N)cc(c1)C(=O)N1CCN(CC1)C(=O)c1ccc(cc1)C(N)=N
Formula
C27H34N8O4
CAS Number
1379573-92-8
Target
Others
Solubility
(<1mg/mL refers to the product slightly soluble or insoluble)
In_vitro
CBB1007 preferentially arrests the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 >= 100uM). hLSD1 CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 <= 5uM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 <= 5uM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 <= 3.74uM).

Product Categories/Family for CBB1007, inhibitor

Others

Structure of CBB1007, inhibitor

CBB1007, CAS 1379573-92-8
CBB1007 Inhibitor – Cat# MBS5766283

Structure of CBB1007, inhibitor

CBB1007, CAS 1379573-92-8
CBB1007 Inhibitor, Structure – Cat# MBS5766283

Product References and Citations for CBB1007, inhibitor

1 Wan J e al Nove histon demethylas LSD inhibitor selectivel targe cance cell wit pluripoten ste cel properties Cance Res 201 De 1 1(23):7238-49.

Other Notes

Small volumes of CBB1007, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CBB1007 purchase

MBS5766283 is an inhibitor targeting CBB1007.
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