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CCT241736 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5750545

CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinical development candidate for the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCT241736, Inhibitor
Full Product Name
CCT241736
Product Gene Name
CCT241736, inhibitor
Product Synonym Names
FLT; Aurora Kinase
Form/Format
POWDER
Purity/Purification
98.0%
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
Molecular Weight
456.37
CAS Number
1402709-93-6
Formula
C22H23Cl2N7
Smiles
Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cnc2[nH]1
Solubility
DMSO: Soluble
Pathways
Tyrosine Kinase; Adaptors; Cell Cycle; Checkpoint
Receptor
FLT3; Aurora Kinase
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Chemical Structure of CCT241736, inhibitor

CCT241736 Inhibitor – Cat# MBS5750545

Product References and Citations for CCT241736, inhibitor

1. Bavetsias V,etal. Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.J Med Chem. 2012 Oct 25; 55(20):8721-34.

Other Notes

Small volumes of CCT241736, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCT241736 purchase

MBS5750545 is an inhibitor targeting CCT241736.
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