CF53 Inhibitor

Name: CF53 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752907
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752907

CF53 is a highly potent, selective, and orally active inhibitor of BET protein (Ki: More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CF53, Inhibitor

Full Product Name

CF53

Product Gene Name

CF53, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

443.5

Solubility

DMSO: 110mg/mL (248.03mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H25N7O2

SMILES

COC1=C(C2=C(C)ON=C2C)C=C(NC3=C4C(NC5=CC(C6CC6)=NN5C)=NC(C)=N3)C4=C1

CAS Number

1808160-52-2

Target & IC50

BRD4(BD1): ic50 2nM
BRD4 BD1: ic50 2.2nM (kd)
BRD4 (BD2): ic50 0.8nM (kd)
BRD2 BD2: ic50 0.6nM (kd)
BRD2 BD1: ic50 1.1nM (kd)
BRD3 BD2: ic50 0.49nM (kd)
BRD3 BD1: ic50 0.52nM (kd)
BRDT BD2: ic50 1nM (kd)
BRDT BD1: ic50 2nM (kd)
CREBBP: ic50 47nM (kd)
EP300: ic50 110nM (kd)
CECR2: ic50 570nM (kd)

In Vitro

In the MDA-MB-231 xenograft tumor model and in RS4;11 models in mice, CF53 (25, 50mg/kg, p.o.) both shows potent anti-tumor activity.

Product Categories/Family for CF53, inhibitor

Chromatin/Epigenetic; Epigenetic Reader Domain

Product References and Citations for CF53, inhibitor

Zhao Y, et al. Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. J Med Chem. 2018 Jul 26;61(14):6110-6120.
Zhao Y, et al. Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. J Med Chem. 2018 Jul 26;61(14):6110-6120.

Other Notes

Small volumes of CF53, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CF53 purchase

MBS5752907 is an inhibitor targeting CF53.