CMP-5 Inhibitor

98%

Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years

315.42

CCn1c2ccccc2c2cc(CNCc3ccccn3)ccc12

C21H21N3

880813-42-3

Others
hTh1 cells: 26.9uM, hTh2 cells: 31.6uM, mTh1 cells: 3.7uM, mTh2 cells: 9.2uM

(<1mg/mL refers to the product slightly soluble or insoluble)

CMP-5 (0-100uM; 24-72hours) is selectively toxic to lymphoma cells but shows limited toxicity to normal resting B lymphocytes even after prolonged incubation. CMP-5 (0-40uM; 24hours) preferentially suppresses the proliferation of Human Th1 cells over Th2 cells (43 versus 9% inhibition, respectively). The sensitivity of Th1 cells over Th2 cells to PRMT5 inhibition is different, the IC50 values are 26.9uM and 31.6uM in Human Th1 cells and Th2 cells, respectively. CMP-5 (40uM; 24hours) decreases p-BTK and pY(416)SRC expression in 60A cells when it compares to the DMSO-treated group. CMP-5 (25uM; 24hours) alone inhibits mouse Th1 cell proliferation by 91%, when added different doses IL-2, IL-2 enhances proliferation and reaches a peak at 5ng/mL [1].