CPP-115 Inhibitor

CPP-115 is a GABA-aminotransferase inhibitor and a high-affinity vigabatrin analogue.

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1 Le H Dou EH W R Sanishvil R Juncos JI Li D Kellehe NL Silverma RB Mechanis o inactivatio o gamma-aminobutyri aci aminotransferas b (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoi aci (CPP-115) A Che Soc 201 Fe 25 37(7):2628-40 doi 10.1021/ja512299n PubMe PMID 25616005 PubMe Centra PMCID PMC4353033 href="javascript:void(0) rel="nofollow >
2 Brigg SW Mowre W Hal CB Galanopoulo AS CPP-115 vigabatri analogue decrease spasm i th multiple-hi ra mode o infantil spasms Epilepsia 201 Jan 5(1):94-102 doi 10.1111/epi.12424 PubMe PMID 24321005 PubMe Centra PMCID PMC4102583 href="javascript:void(0) rel="nofollow >
3 DuMlel K Conwa E Hedlun J Tolet P Devinsk O cas repor o th efficac o vigabatri analogu (1S 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoi aci (CPP-115 i patien wit infantil spasms Epileps Beha Cas Rep 201 Au 21 :67-9 doi 10.1016/j.ebcr.2016.08.002 PubMe PMID 27668180 PubMe Centra PMCID PMC5024311 href="javascript:void(0) rel="nofollow >
4 Pa Y Gerasimo MR Kvis T Wellendorp P Madse KK Per E Le H Schousbo A Chebi M Bräuner-Osborn H Craf CM Brodi JD Schiffe WK Dewe SL Mille SR Silverma RB (1S 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoi aci (CPP-115) poten gamma-aminobutyri aci aminotransferas inactivato fo th treatmen o cocain addiction Me Chem 201 Ja 12 5(1):357-66 doi 10.1021/jm201231w PubMe PMID 22128851 PubMe Centra PMCID PMC3257419.

Small volumes of CPP-115, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5776796 is an inhibitor targeting CPP-115.