DAPTA Inhibitor – (TFA)

MBS5758514 is an inhibitor targeting DAPTA. Also known as DAPTA (TFA). DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.

Pollicita M, Ruff M R, Pert C B, et al. Profound Anti-HIV-1 Activity of DAPTA in Monocytes/macrophages and Inhibition of CCR5-mediated Apoptosis in Neuronal Cells[J]. Antiviral Chemistry and Chemotherapy, 2007, 18(5):285-295.
Pollicita M, Ruff M R, Pert C B, et al. Profound Anti-HIV-1 Activity of DAPTA in Monocytes/macrophages and Inhibition of CCR5-mediated Apoptosis in Neuronal Cells[J]. Antiviral Chemistry and Chemotherapy, 2007, 18(5):285-295.
Michael R. Ruff, Maria Polianova, Quan-en Yang, Gifford S. Leoung, Francis W. Ruscetti, Candace B. Pert. Update on D-Ala-Peptide T-Amide (DAPTA): A Viral Entry Inhibitor that Blocks CCR5 Chemokine Receptors[J]. Current HIV Research, 2003, 1(1):p.51-67.
Michael R. Ruff, Maria Polianova, Quan-en Yang, Gifford S. Leoung, Francis W. Ruscetti, Candace B. Pert. Update on D-Ala-Peptide T-Amide (DAPTA): A Viral Entry Inhibitor that Blocks CCR5 Chemokine Receptors[J]. Current HIV Research, 2003, 1(1):p.51-67.

Small volumes of DAPTA, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.