ETP-46321 Inhibitor

Name: ETP-46321 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764481
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764481

ETP-46321 is an effective and orally bioavailable PI3Kalpha/PI3Kdelta inhibitor (Ki: 2.3/14.2nM). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ETP-46321, Inhibitor

Full Product Name

ETP-46321

Product Gene Name

ETP-46321, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

473.55

Solubility

DMSO: 30mg/mL (63.35mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H27N9O3S

SMILES

NC(N=C1)=NC=C1C2=CN3C=C(CN4CCN(S(=O)(C)=O)CC4)N=C3C(N5CCOCC5)=N2

CAS Number

1252594-99-2

In Vitro

ETP-46321 is selected for in vivo studies based on its appealing pharmacokinetic profile in BALB-C mice, low in vivo Clearance (0.6 L/h/Kg) and good oral bioavailability (90%). ETP-46321 demonstrates a good pharmacokinetic profile in mice and is selected for preliminary in vivo evaluation in a lung tumor mouse model driven by a K-RasG12V oncogenic mutation, showing significant tumor growth inhibition.

Product Categories/Family for ETP-46321, inhibitor

PI3K/Akt/mTOR signaling; PI3K

Product References and Citations for ETP-46321, inhibitor

Martinez Gonzalez S, et al. Identification of ETP-46321, a potent and orally bioavailable PI3K alpha, delta inhibitor. Bioorg Med Chem Lett. 2012 May 15;22(10):3460-6.

Other Notes

Small volumes of ETP-46321, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ETP-46321 purchase

MBS5764481 is an inhibitor targeting ETP-46321.