Exisulind Inhibitor

98.08%

Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years

372.41

CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)(=O)=O

C20H17FO4S

59973-80-7

Apoptosis|||PKA

(<1mg/mL refers to the product slightly soluble or insoluble)

The topical treatment with NO-Exisulind significantly reduced UVB-induced tumors in SKH-1 hairless mice. The tumors/uMor bearing mouse, the number of tumors/mouse and tumor volume/mouse decreased significantly (P <0.05) as compared with vehicle-treated and UVB-irradiated positive controls. NO-Exisulind-treated animals showed reduced expression of proliferation markers, such as PCNA and cyclin D1. These mice also manifested increased expression of proapoptotic Bax and decreased expression of antiapoptotic Bcl2 with an increase in the number of TUNEL-positive cells in tumors. NO-Exisulind-treated tumors are less invasive and progress less efficiently from benign to malignant carcinomas[1].

Apoptosis; Tyrosine Kinase/Adaptors