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FK-506 (Tacrolimus) Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS384718

MBS384718 is an inhibitor targeting FK-506 (Tacrolimus). More details

$160 / 50 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FK-506 (Tacrolimus), Inhibitor
Full Product Name
FK-506 (Tacrolimus)
Product Synonym Names
FK506; Fujimycin; Prograf; Tacrolimus
Form/Format
Powder
Purity/Purification
>98%
Concentration
0.1 mM: 12.44 mL (1 mg); 62.19 mL (5 mg); 124.38mL (10 mg)
0.5 mM: 2.49 mL (1 mg); 12.44 mL (5 mg); 24.88 mL (10 mg)
1 mM: 1.24 mL (1 mg); 6.22 mL (5 mg); 12.44 mL (10 mg)
5 mM: 0.25 mL (1 mg); 1.24 mL (5 mg); 2.49 mL (10 mg) (lot specific)
Preparation and Storage
Store at -20°C, stable for 1 year in powder form or stable for 6 months in solution base form
Molecular Weight
804
CAS Number
104987-11-3
Formula
C44H69NO12
SMILES
C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
Targets
FKBP12 (T cells)
Solubility
DMSO: 81 mg/mL (100.74 mM)
Ethanol: 71 mg/mL (88.31 mM)
Water: Insoluble
In vivo
5% DMSO+corn oil : 14mg/mL

* <1 mg/ml means slightly soluble or insoluble.
* Please note that the labs QC internal testing, tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Biological Activity
FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.

Chemical Structure of FK-506 (Tacrolimus), inhibitor

FK-506 (Tacrolimus) Inhibitor – Cat# MBS384718

Product References and Citations for FK-506 (Tacrolimus), inhibitor

Ogawa Y, .et al. Inhibition of astrocytic adenosine receptor A2A attenuates microglial activation in a mouse model of Sandhoff disease, Neurobiol Dis, 2018, Oct;118:142-154 PMID: 30026035
Yuko Okamoto, .et al. In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers, J Drug Deliv Sci Technol, 2018, 47: 62-66

Other Notes

Small volumes of FK-506 (Tacrolimus), inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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