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FR194738 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5766676

FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8nM. FR194738 free base is a squalene epoxidase inhibitor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FR194738, Inhibitor
Full Product Name
FR194738 free base
Product Gene Name
FR194738, inhibitor
Purity/Purification
98%
Preparation and Storage
Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years
Molecular Weight
439.66
SMILES
CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCC(C)(C)OCc2ccsc2)c1
Formula
C27H37NO2S
CAS Number
204067-45-8
Target
Antifungal
squalene epoxidase, in HepG2 cell homogenates: 9.8nM
Solubility
(<1mg/mL refers to the product slightly soluble or insoluble)
In_vitro
FR194738 reduces the serum levels of total, non high density lipoprotein (HDL) and HDL cholesterol, and triglyceride. Treatment of hamsters with FR194738 increases HMG-CoA reductase activity by 1.3-fold at 32mg/kg compared to the control group and does not significantly change that at 100mg/kg. FR194738 potently inhibits squalene epoxidase (SE) in HepG2 cell homogenate and liver serum lipid levels in hamsters after daily administration of FR194738 and Pravastatin for 10 d are measured.

Product Categories/Family for FR194738, inhibitor

Microbiology/Virology

Structure of FR194738, inhibitor

FR194738 free base, CAS 204067-45-8
FR194738 Inhibitor – Cat# MBS5766676

Structure of FR194738, inhibitor

FR194738 free base, CAS 204067-45-8
FR194738 Inhibitor, Structure – Cat# MBS5766676

Product References and Citations for FR194738, inhibitor

1 Sawad M e al Effec o FR194738 poten inhibito o squalen epoxidase o cholestero metabolis i HepG cells Eu Pharmacol 200 No 9 31(1):11-6.
2 Sawad M e al Synthesi an biologica activit o nove squalen epoxidas inhibitor FR194738 Bioor Me Che Lett 200 Fe 9 4(3):633-7.
3 Sawad M e al Inhibitio o cholestero synthesi cause bot hypercholesterolemi an hypocholesterolemi i hamsters Bio Phar Bull 200 Dec 5(12):1577-82.

Other Notes

Small volumes of FR194738, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FR194738 purchase

MBS5766676 is an inhibitor targeting FR194738. Also known as FR194738 free base.
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