GNF 5837 Inhibitor

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.

Tanimizu N, .et al. Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver, Development, 2018, Apr 25;145(9). pii: dev159095 PMID: 29615468
Shargh VH, .et al. Gelatin-albumin hybrid nanoparticles as matrix metalloproteinases-degradable delivery systems for breast cancer therapy, Nanomedicine (Lond), 2017, May;12(9):977-989 PMID: 28440712
Shargh VH, .et al. Albumin hybrid nanoparticles loaded with tyrosine kinase A inhibitor GNF-5837 for targeted inhibition of breast cancer cell growth and invasion, Int J Pharm, 2016, Dec 30;515(1-2):527-534 PMID: 27793712

Small volumes of GNF 5837, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS384783 is an inhibitor targeting GNF 5837.