IQ3 Inhibitor

Name: IQ3 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5759271
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5759271

IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66nM, 240nM and 290nM, respectively). IQ 3 inhibits NF-kappaB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4uM, also inhibits TNF-alpha and IL-6 production in vitro. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IQ3, Inhibitor

Full Product Name

IQ3

Product Gene Name

IQ3, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

341.32

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C20H11N3O3

SMILES

O=C(ON=C1C2=CC=CC=C2C2=NC3=CC=CC=C3N=C12)C1=CC=CO1

CAS Number

312538-03-7

Target & IC50

JNK3: ic50 66nM (Kd)
JNK1: ic50 240nM (Kd)
JNK2: ic50 290nM (Kd)

Product Categories/Family for IQ3, inhibitor

MAPK; JNK

Product References and Citations for IQ3, inhibitor

Schepetkin I A, Kirpotina L N, Khlebnikov A I, et al. Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors[J]. Molecular Pharmacology, 2012, 81(6):832-845.

Other Notes

Small volumes of IQ3, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IQ3 purchase

MBS5759271 is an inhibitor targeting IQ3.