Leachianone A Inhibitor

Name: Leachianone A Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760577
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760577

Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Leachianone A, Inhibitor

Full Product Name

Leachianone A

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

438.5

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C26H30O6

SMILES

CC(C)=CC[C@H](Cc(c(O[C@@H](CC1=O)c(ccc(O)c2)c2OC)c1c(O)c1)c1O)C(C)=C

CAS Number

97938-31-3

Target & IC50

SGLT

In Vitro

In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment, Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed[1]

Product Categories/Family for Leachianone A, inhibitor

GPCR/G Protein; SGLT

Product References and Citations for Leachianone A, inhibitor

Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells.Cancer Lett. 2007 Aug 18;253(2):224-35.
Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells.Cancer Lett. 2007 Aug 18;253(2):224-35.
Lavandulyl flavonoids with sodium-dependent glucose cotransporter 2 inhibitory activity from Sophora flavescens.Journal of Huazhong Normal University, 2014, 48(4):520-4.

Other Notes

Small volumes of Leachianone A, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Leachianone A purchase

MBS5760577 is an inhibitor targeting Leachianone A.