• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

M77976 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5769425

M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4)(IC50: 648uM). More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
M77976, Inhibitor
Full Product Name
M77976
Product Gene Name
M77976, inhibitor
Purity/Purification
98%
Preparation and Storage
Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years
Molecular Weight
296.326
SMILES
COc1ccc(cc1)-c1c(C)[nH]nc1-c1ccc(O)cc1O
Formula
C17H16N2O3
CAS Number
394237-61-7
Target
GluR
PDK4: 648uM
Solubility
(<1mg/mL refers to the product slightly soluble or insoluble)
In_vitro
M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306, and Thr358 of PDK4. M77976 binds to the ATP-binding pocket of PDK4 and induces local conformational changes with complete disordering of the ATP lid.

Product Categories/Family for M77976, inhibitor

Neuroscience

Structure of M77976, inhibitor

M77976, CAS 394237-61-7
M77976 Inhibitor – Cat# MBS5769425

Structure of M77976, inhibitor

M77976, CAS 394237-61-7
M77976 Inhibitor, Structure – Cat# MBS5769425

Product References and Citations for M77976, inhibitor

1 Kukimoto-Niin M e al Inhibitor-boun structure o PUMA pyruvat dehydrogenas kinas 4 Act Crystallog Bio Crystallogr 201 Sep 7(P 9):763-73.

Other Notes

Small volumes of M77976, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for M77976 purchase

MBS5769425 is an inhibitor targeting M77976.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000