Mivotilate Inhibitor

Name: Mivotilate Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755191
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755191

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR). It acts as a hepatoprotective agent. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Mivotilate, Inhibitor

Full Product Name

Mivotilate

Product Synonym Names

YH439

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

330.45

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C12H14N2O3S3

SMILES

O=C(OC(C)C)/C(C(NC1=NC(C)=CS1)=O)=C2SCS\2

CAS Number

130112-42-4

Target & IC50

Aryl hydrocarbon receptor

In Vitro

Mivotilate (150mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats. Mivotilate (75-300mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150mg/kg, p.o.) decreases CYP2E1-mediated NDMA demethylase activity in rats but displays no obvious effect on NADPH-dependent P450 oxidoreductase activity [2].

Product Categories/Family for Mivotilate, inhibitor

Immunology/Inflammation

Product References and Citations for Mivotilate, inhibitor

Whelan F, et al. Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Mol Pharmacol. 2010 Jun;77(6):1037-46.
Whelan F, et al. Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Mol Pharmacol. 2010 Jun;77(6):1037-46.
Jeong KS, et al. Transcriptional inhibition of cytochrome P4502E1 by a synthetic compound, YH439. Arch Biochem Biophys. 1996 Feb 1;326(1):137-44.
Jeong KS, et al. Transcriptional inhibition of cytochrome P4502E1 by a synthetic compound, YH439. Arch Biochem Biophys. 1996 Feb 1;326(1):137-44.
Lee IJ, et al. Transcriptional induction of the cytochrome P4501A1 gene by a thiazolium compound, YH439. Mol Pharmacol. 1996 Jun;49(6):980-8.
Lee IJ, et al. Transcriptional induction of the cytochrome P4501A1 gene by a thiazolium compound, YH439. Mol Pharmacol. 1996 Jun;49(6):980-8.

Other Notes

Small volumes of Mivotilate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mivotilate purchase

MBS5755191 is an inhibitor targeting Mivotilate.