MRT67307 Inhibitor

Name: MRT67307 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5751607
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5751607

MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKepsilon, and NUAK1 (IC50: 19, 27-52, 160, and 230nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MRT67307, Inhibitor

Full Product Name

MRT67307 HCl (1190378-57-4 (free base))

Product Gene Name

MRT67307, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Formula

C26H36N6O2·xHCl

Smiles

Cl.O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1

Receptor (IC50)

IKK: 160nM (cell free)
TBK1: 19nM (cell free)
ULK1: 45nM (cell free
ULK2: 38nM (cell free)

Solubility

DMSO: 50mg/mL
Water: 10mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for MRT67307, inhibitor

Home; NF-kappab; IkappaB/IKK; MRT67307 HCl (1190378-57-4 (free base))

Product References and Citations for MRT67307, inhibitor

1. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434 (1):93-104.
2. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290 (18):11376-83.
3. Clark K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109 (42):161986-91.

Other Notes

Small volumes of MRT67307, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRT67307 purchase

MBS5751607 is an inhibitor targeting MRT67307. Also known as MRT67307 HCl (1190378-57-4 (free base)).