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Nelfinavir Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758646

Nelfinavir is an antiretroviral drug used in the treatment,of the human immunodeficiency virus (HIV) (Ki=2nM). Nelfinavir is a broad-spectrum, anticancer agent. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nelfinavir, Inhibitor
Full Product Name
Nelfinavir
Product Synonym Names
AG1341
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
567.78
Solubility
DMSO: 100mg/mL (176.12mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C32H45N3O4S
SMILES
Cc1c(O)cccc1C(=O)NC(CSc1ccccc1)C(O)CN1CC2CCCCC2CC1C(=O)NC(C)(C)C
CAS Number
159989-64-7
Target & IC50
HIV: ic50 2nM (ki)
In Vitro
Nelfinavir decreased the viability of a panel of drug-resistant breast cancer cell lines and inhibited the growth of NSCLC xenografts that was associated with induction of ER stress, autophagy, and apoptosis. Nelfinavir is a lead HIV protease inhibitor with pleiotropic effects in cancer cells[1]

Product References and Citations for Nelfinavir, inhibitor

Gills J. Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo[J]. Clin Cancer Res, 2007, 13(17):5183.
Gills J. Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo[J]. Clin Cancer Res, 2007, 13(17):5183.
Mondal D, Liu K, Hamblin M, et al. Nelfinavir Suppresses Insulin Signaling and Nitric Oxide Production by Human Aortic Endothelial Cells: Protective Effects of Thiazolidinediones[J]. ochsner journal, 2013, 13(1):76.
Mondal D, Liu K, Hamblin M, et al. Nelfinavir Suppresses Insulin Signaling and Nitric Oxide Production by Human Aortic Endothelial Cells: Protective Effects of Thiazolidinediones[J]. ochsner journal, 2013, 13(1):76.

Other Notes

Small volumes of Nelfinavir, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nelfinavir purchase

MBS5758646 is an inhibitor targeting Nelfinavir.
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