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Nevanimibe Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5767200

Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1)(EC50 of 9nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nevanimibe, Inhibitor
Full Product Name
Nevanimibe
Product Synonym Names
PD-132301; ATR-101
Purity/Purification
98%
Preparation and Storage
Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years
Molecular Weight
421.629
SMILES
CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(CCCC1)c1ccc(cc1)N(C)C
Formula
C27H39N3O
CAS Number
133825-80-6
Target
Others
ACAT2: 368nM (EC50), ACAT1: 9nM (EC50)
Solubility
(<1mg/mL refers to the product slightly soluble or insoluble)
In_vitro
In H295R Human adrenocortical carcinoma cells, Nevanimibe(ATR-101) decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity. Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis[1].

Product Categories/Family for Nevanimibe, inhibitor

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Structure of Nevanimibe, inhibitor

Nevanimibe, CAS 133825-80-6
Nevanimibe Inhibitor – Cat# MBS5767200

Structure of Nevanimibe, inhibitor

Nevanimibe, CAS 133825-80-6
Nevanimibe Inhibitor, Structure – Cat# MBS5767200

Product References and Citations for Nevanimibe, inhibitor

1 LaPense CR e al ATR-101 Selectiv an Poten Inhibito o Acyl-Co Acyltransferas 1 Induce Apoptosi i H295 Adrenocortica Cell an i th Adrena Corte o Dogs Endocrinology 201 May 57(5):1775-88.

Other Notes

Small volumes of Nevanimibe, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nevanimibe purchase

MBS5767200 is an inhibitor targeting Nevanimibe.
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