NSI-189 Inhibitor – Phosphate

NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.

Tajiri N, Quach D M, Kaneko Y, et al. NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats[J]. Journal of Cellular Physiology, 2017.
Karl K Johe, Gary Kay, Santosh Kumar, et al.NSI-189 phosphate, a novel neurogenic compound, selectively benefits moderately depressed patients: A post-hoc analysis of a phase 2 study of major depressive disorder. Ann Clin Psychiatry. 2020 Aug;32(3):182-196.
Karl K Johe, Gary Kay, Santosh Kumar, et al.NSI-189 phosphate, a novel neurogenic compound, selectively benefits moderately depressed patients: A post-hoc analysis of a phase 2 study of major depressive disorder. Ann Clin Psychiatry. 2020 Aug;32(3):182-196.

Small volumes of NSI-189, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756672 is an inhibitor targeting NSI-189. Also known as NSI-189 Phosphate.