Progabide Inhibitor

98%

Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years

334.78

NC(=O)CCC\N=C(\c1ccc(Cl)cc1)c1cc(F)ccc1O

C17H16ClFN2O2

62666-20-0

GABA Receptor

(<1mg/mL refers to the product slightly soluble or insoluble)

Progabide (50, 100 and 200mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide[1].

Membrane transporter/Ion channel; Neuroscience