RO15-4513 Inhibitor

Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.

Bonetti EP, et al. Ro 15-4513: partial inverse agonism at the BZR and interaction with ethanol. Pharmacol Biochem Behav. 1988 Nov;31(3):733-49.
Bonetti EP, et al. Ro 15-4513: partial inverse agonism at the BZR and interaction with ethanol. Pharmacol Biochem Behav. 1988 Nov;31(3):733-49.
Suzdak PD, et al. Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-inducedintoxication in the rat. J Pharmacol Exp Ther. 1988 Jun;245(3):880-6.
Suzdak PD, et al. Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-inducedintoxication in the rat. J Pharmacol Exp Ther. 1988 Jun;245(3):880-6.
Linden AM, et al. Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through alphabetagamma2-type GABA(A) Receptors. Front Neurosci. 2011 Jan 20;5:3.
Linden AM, et al. Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through alphabetagamma2-type GABA(A) Receptors. Front Neurosci. 2011 Jan 20;5:3.

Small volumes of Ro15-4513, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5755472 is an inhibitor targeting Ro15-4513.