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Senicapoc Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS579653

MBS579653 is an inhibitor targeting Senicapoc. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Senicapoc, Inhibitor
Full Product Name
Senicapoc
Form/Format
POWDER
Purity/Purification
99.50%
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
Molecular Weight
323.11
CAS
289656-45-7
Formula
C20H15F2NO
Pathways
Membrane transporter/Ion channel
Target
RBC dehydration
Smiles
NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Receptor
Gardos channel
Bioactivity
Senicapoc is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 +/- 2 nM (CLT IC50 = 100 +/- 12 nM) and inhibited RBC dehydration with an IC50 of 30 +/- 20 nM. Senicapoc is in treatment of Sickle Cell Disease and Sickle Cell Anemia
Solubility
DMSO: Soluble
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Structure of Senicapoc, inhibitor

Senicapoc Inhibitor – Cat# MBS579653

Product References and Citations for Senicapoc, inhibitor

1. Ataga KI, et al. Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia. Expert Opin Investig Drugs. 2009 Feb; 18 (2):231-9.

Other Notes

Small volumes of Senicapoc, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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