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SIS3 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5767611

SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-beta1. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SIS3, Inhibitor
Full Product Name
SIS3 free base
Product Gene Name
Purity/Purification
98%
Preparation and Storage
Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years
Molecular Weight
453.542
SMILES
COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c1c(-c2ccccc2)n(C)c2ncccc12
Formula
C28H27N3O3
CAS Number
1009104-85-1
Target
TGF-beta/Smad
Solubility
(<1mg/mL refers to the product slightly soluble or insoluble)
In_vitro
SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.

Product Categories/Family for SIS3, inhibitor

Structure of SIS3, inhibitor

SIS3 free base, CAS 1009104-85-1
SIS3 Inhibitor – Cat# MBS5767611

Structure of SIS3, inhibitor

SIS3 free base, CAS 1009104-85-1
SIS3 Inhibitor, Structure – Cat# MBS5767611

Product References and Citations for SIS3, inhibitor

1 Jinni M e al Characterizatio o SIS3 nove specifi inhibito o Smad3 an it effec o transformin growt factor-beta1-induce extracellula matri expression Mo Pharmacol 200 Feb 9(2):597-607 Epu 200 No 15.

Other Notes

Small volumes of SIS3, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIS3 purchase

MBS5767611 is an inhibitor targeting SIS3. Also known as SIS3 free base.

Additional Details

NCBI/Uniprot data below describe general gene information for SIS3. It may not necessarily be applicable to this product.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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