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SM-1295 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5785010

SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077nM, 3.2nM and 9.5nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively[1][2]. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SM-1295, Inhibitor
Full Product Name
SM-1295
Product Gene Name
SM-1295, inhibitor
Purity/Purification
98%
Preparation and Storage
Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years
Molecular Weight
598.53
Formula
C29H36BrN5O4
CAS Number
1562375-46-5
Target
XIAP-BIR3: 3077nM (Kd), c-IAP1-BIR3: 3.2nM (Kd), c-IAP2-BIR3: 9.5nM (Kd)
Solubility
(<1mg/mL refers to the product slightly soluble or insoluble)
In_vitro
SM-1295 (compound 5) binds to both cIAP1 and cIAP2 proteins with Ki values of 900-fold for cIAP1 over XIAP[1].SM-1295 (compound 5) exhibits an IC50 of 46nM in MDA-MB-231[1].

Structure of SM-1295, inhibitor

SM-1295, CAS 1562375-46-5
SM-1295 Inhibitor – Cat# MBS5785010

Structure of SM-1295, inhibitor

SM-1295, CAS 1562375-46-5
SM-1295 Inhibitor, Structure – Cat# MBS5785010

Product References and Citations for SM-1295, inhibitor

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1 Haiyin Sun e al Poten an Selectiv Small-Molecul Inhibitor o cIAP1/ Protein Revea Tha th Bindin o Sma Mimetic t XIA BIR I No Require fo Thei Effectiv Inductio o Cel Deat i uMo Cells AC Che Biol 201 Ap 18 (4):994-1002 href="javascript:void(0) rel="nofollow >
2 Hu Cong e al Inhibito o Apoptosi Protei (IAP Antagonist i Anticance Agen Discovery Curren Statu an Perspectives Me Chem 201 Ju 27 2(12):5750-5772.

Other Notes

Small volumes of SM-1295, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SM-1295 purchase

MBS5785010 is an inhibitor targeting SM-1295.
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