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SW-100 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755571

SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SW-100, Inhibitor
Full Product Name
SW-100
Product Gene Name
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
316.78
Solubility
DMSO: 125mg/mL (394.60mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H17ClN2O2
SMILES
ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
CAS Number
2126744-35-0
Target & IC50
HDAC1: ic50 5.23uM
HDAC2: ic50 32.8uM
HDAC3: ic50 29.5uM
HDAC4: ic50 10.9uM
HDAC5: ic50 4.07uM
HDAC6: ic50 2.3nM
HDAC7: ic50 4.55uM
HDAC8: ic50 3.72uM
HDAC9: ic50 3.46uM
HDAC10: ic50 26.2uM
HDAC11: ic50 5.72uM
In Vitro
In mouse model of Fragile X syndrome, SW-100 (20mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing [1].

Structure of SW-100, inhibitor

SW-100 Inhibitor – Cat# MBS5755571

Product References and Citations for SW-100, inhibitor

Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.
Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.

Other Notes

Small volumes of SW-100, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SW-100 purchase

MBS5755571 is an inhibitor targeting SW-100.

Additional Details

NCBI/Uniprot data below describe general gene information for SW-100. It may not necessarily be applicable to this product.

Protein Family

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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