VZ185 Inhibitor

Name: VZ185 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755708
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755708

VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VZ185, Inhibitor

Full Product Name

VZ185

Product Gene Name

VZ185, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

995.21

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C53H67FN8O8S

SMILES

O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3OCCCCCN5CCN(CC6=C(OC)C=C(C(C7=CC=NC=C87)=CN(C)C8=O)C=C6OC)CC5

CAS Number

2306193-61-1

Target & IC50

BRD7: ic50 4.5nM (DC50)
BRD9: ic50 1.8nM (DC50)

Product Categories/Family for VZ185, inhibitor

Chromatin/Epigenetic; Epigenetic Reader Domain; Epigenetics

Product References and Citations for VZ185, inhibitor

1. Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62(2):699-726.

Other Notes

Small volumes of VZ185, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VZ185 purchase

MBS5755708 is an inhibitor targeting VZ185.