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Wortmannin Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS386181

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM). More details

$190 / 1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Wortmannin, Inhibitor
Full Product Name
Wortmannin
Product Synonym Names
SL-2052
Form/Format
Powder
Purity/Purification
>98%
Concentration
0.1 mM: 23.34 mL (1 mg); 116.71 mL (5 mg); 233.41mL (10 mg)
0.5 mM: 4.67 mL (1 mg); 23.34 mL (5 mg); 46.68 mL (10 mg)
1 mM: 2.33 mL (1 mg); 11.67 mL (5 mg); 23.34 mL (10 mg)
5 mM: 0.47 mL (1 mg); 2.33 mL (5 mg); 4.67 mL (10 mg) (lot specific)
Preparation and Storage
at -20 degree C 3 years Powder
Molecular Weight
428.43
CAS Number
19545-26-7
Formula
C23H24O8
SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
Actions
Inhibitor
In Vivo Solvent
1% DMSO/30% polyethylene glycol/1% Tween 80
Solubility (DMSO)
86 mg/mL (200.73 mM)
Solubility (Ethanol)
<1 mg/mL (<1 mM)
Solubility (in vivo)
8 mg/mL
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.

Chemical Structure of Wortmannin, inhibitor

Wortmannin Inhibitor – Cat# MBS386181

Product References and Citations for Wortmannin, inhibitor

Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546 -1558.

Other Notes

Small volumes of Wortmannin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Wortmannin purchase

MBS386181 is an inhibitor targeting Wortmannin.
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