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YCH1899 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5821328

YCH1899, an orally active PARP Inhibitor, demonstrates potent inhibition of PARP1/2 with an IC50 of less than 0.001 nM. It shows marked antiproliferative efficacy against Olaparib-resistant (Capan-1/OP) and Talazoparib-resistant (Capan-1/TP) cells with IC50… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
YCH1899, Inhibitor
Full Product Name
YCH1899
Product Gene Name
YCH1899, inhibitor
Preparation and Storage
Powder: -20 degree C for 3 years | In solvent: -80 degree C for 1 year
Molecular Weight
549.35
Formula
C25H18BrFN6O3
Solubility
(< 1 mg/ml refers to the product slightly soluble or insoluble)
Targets&IC50
TNKS1: 3.8 nM (EC50), PARP4: 1.0 nM, TNKS2: 12.4 nM, PARP-7: 7.3 nM, ARTD10/PARP10: 10.8 nM, PARP14: 35.914uM, PARP15: 51.623 nM, PARA6: 9.5 nM, PARA11: 2.166uM, human PARP12: 14.1 nM, PARP-1: <0.001 nM, PARP3: 1.1 nM, PARP-2: <0.001 nM
In_vitro
YCH1899, administered intravenously at a dose of 5 mg/kg, demonstrated moderate clearance in rats [1]. The compound successfully overcame Talazoparib resistance in xenograft mouse tumor models of MDA-MB-436/OP and Capan-1/R, with significant tumor volume reduction observed at oral doses of 6.25, 12.5, and 25 mg/kg once daily for 27 days and 12.5 and 25 mg/kg once daily for 21 days, respectively [1].

Other Notes

Small volumes of YCH1899, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for YCH1899 purchase

MBS5821328 is an inhibitor targeting YCH1899.
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