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LRPAP1 protein :: RAP Protein

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Catalog # MBS135849
Unit / Price
  0.5 mg  /  $630 +1 FREE 8GB USB
  1 mg  /  $1,040 +1 FREE 8GB USB
LRPAP1 protein
Product Name

RAP (LRPAP1), Protein

Popular Item
Also Known As

Human RAP

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
357
Chromosome Location
Chromosome: 4; NC_000004.11 (3505324..3534224, complement). Location: 4p16.3
OMIM
104225
3D Structure
ModBase 3D Structure for P30533
Host
E. coli
Purity/Purification
>90% by SDS-PAGE analysis
Form/Format
Frozen liquid
Concentration
2.5 mg/ml (lot specific)
Buffer
0.1M Tris-HCl; 0.1M NaCl; pH 7.4
Extinction Coefficient
0.93
Preparation and Storage
Store at -70 degree C. Shelf Life: 3 years from delivery
Other Notes
Small volumes of LRPAP1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
LRPAP1 protein
Produced recombinantly in E. Coli. Suitable to block receptor function in uptake assays. Contains endotoxin which might trigger signaling events.
NCBI/Uniprot data below describe general gene information for LRPAP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,000
NCBI Official Full Name
alpha-2-macroglobulin receptor-associated protein
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein associated protein 1
NCBI Official Symbol
LRPAP1  [Similar Products]
NCBI Official Synonym Symbols
RAP; MRAP; A2RAP; HBP44; A2MRAP
  [Similar Products]
NCBI Protein Information
alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; lipoprotein receptor associated protein; alpha-2-macroglobulin receptor-associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
UniProt Protein Name
Alpha-2-macroglobulin receptor-associated protein
UniProt Synonym Protein Names
Low density lipoprotein receptor-related protein-associated protein 1
UniProt Gene Name
LRPAP1  [Similar Products]
UniProt Synonym Gene Names
A2MRAP; Alpha-2-MRAP; RAP  [Similar Products]
UniProt Entry Name
AMRP_HUMAN
NCBI Summary for LRPAP1
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
UniProt Comments for LRPAP1
LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: cell surface; endoplasmic reticulum; integral to membrane; plasma membrane; extracellular region; vesicle

Molecular Function: heparin binding; receptor antagonist activity; protein binding; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity

Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding

Disease: Myopia 23, Autosomal Recessive
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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