EPHX2 Lysate – Tissue Lysate

This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

EPHX2: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate. Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.

Protein type: Lipid Metabolism - arachidonic acid; EC 3.1.3.76; EC 3.3.2.10; Hydrolase

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: cytoplasm; peroxisome; cytosol

Molecular Function: toxin binding; protein homodimerization activity; lipid-phosphate phosphatase activity; epoxide hydrolase activity; phosphoric monoester hydrolase activity; magnesium ion binding; lipid phosphatase activity; receptor binding

Biological Process: response to toxin; epoxygenase P450 pathway; stilbene catabolic process; positive regulation of vasodilation; phospholipid dephosphorylation; cellular calcium ion homeostasis; cholesterol homeostasis; dephosphorylation; regulation of blood pressure; xenobiotic metabolic process; arachidonic acid metabolic process; drug metabolic process; inflammatory response

Disease: Hypercholesterolemia, Familial