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FBXO45 Lysate – Tissue Lysate

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8411651

Human FBXO45 Protein Lysate 20ug is provided as a Lyophilized powder.This is a Recombinant Protein Lysate produced in HEK293T cells. This protein lysate can be reconsituted using SDS Sample Buffer. More details

$390 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FBXO45, Lysate
Full Product Name
Human FBXO45 Protein Lysate
Product Gene Name
FBXO45 lysate
Product Synonym Names
FBXO45; Fbx45; Fbx45
Host
Human
Form/Format
Lyophilized
Preparation and Storage
Store at -20 degree C
Once reconsituted, aliquot and store any remaining material at-20 degree C to avoid repeated freeze-thaw cycles.
Molecular Weight
31kDa
OMIM
609112
3D Structure
ModBase 3D Structure for P0C2W1

Other Notes

Small volumes of FBXO45 lysate vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FBXO45 purchase

MBS8411651 is a lysate targeting FBXO45. Also known as Human FBXO45 Protein Lysate. Host: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for FBXO45. It may not necessarily be applicable to this product.

NCBI GI #
157743247
NCBI GeneID
200933
NCBI Accession #
NP_001099043
UniProt Primary Accession #
P0C2W1
UniProt Related Accession #
P0C2W1
GenBank Nucleotide #
NM_001105573
NCBI Official Full Name
F-box/SPRY domain-containing protein 1
NCBI Official Synonym Full Names
F-box protein 45
NCBI Official Symbol
FBXO45
NCBI Official Synonym Symbols
Fbx45
UniProt Protein Name
F-box/SPRY domain-containing protein 1
UniProt Synonym Protein Names
F-box only protein 45; hFbxo45
UniProt Gene Name
FBXO45
UniProt Synonym Gene Names
FBX45; hFbxo45
UniProt Entry Name
FBSP1_HUMAN
NCBI Protein Information
F-box/SPRY domain-containing protein 1

NCBI Summary for FBXO45

Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]
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UniProt Comments for FBXO45

FBXO45: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons. May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation. Belongs to the FBXO45/Fsn family.

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: presynaptic membrane; postsynaptic membrane; postsynaptic density; cell junction

Molecular Function: protein binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; anterior commissure morphogenesis; cerebral cortex tangential migration; protein ubiquitination during ubiquitin-dependent protein catabolic process; neuron migration; protein ubiquitination; cerebral cortex radially oriented cell migration; corticospinal tract morphogenesis; response to DNA damage stimulus
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Research Articles on FBXO45

1. Relatively low FBXO45 expression in gastric cancer tissues is associated with cancer progression and constitutes an independent prognostic factor

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FBXO45 lysate

 Reference Product  PubMed Publications
 MYCBP2 lysate  >4 publications with FBXO45 and MYCBP2
 SKP1 lysate  >4 publications with FBXO45 and SKP1
 FBXL18 lysate  >1 publications with FBXO45 and FBXL18
 UNC13A lysate  >1 publications with FBXO45 and UNC13A

Diseases associated with FBXO45 lysate

 Disease Name  Pubmed Publications
 Death Antibodies  >3 publications with FBXO45 and Death
 Neurobehavioral Manifestations Antibodies  >2 publications with FBXO45 and Neurobehavioral Manifestations
 Brain Diseases Antibodies  >1 publications with FBXO45 and Brain Diseases
 Abnormalities, Multiple Antibodies  >1 publications with FBXO45 and Abnormalities, Multiple
 Inflammation Antibodies  >1 publications with FBXO45 and Inflammation
 Learning Disorders Antibodies  >1 publications with FBXO45 and Learning Disorders

Organs/Tissues associated with FBXO45 lysate

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with FBXO45 and Brain
 Prostate Antibodies  >2 publications with FBXO45 and Prostate
 Kidney Antibodies  >1 publications with FBXO45 and Kidney
 Liver Antibodies  >1 publications with FBXO45 and Liver
 Parathyroid Antibodies  >1 publications with FBXO45 and Parathyroid
 Lung Antibodies  >1 publications with FBXO45 and Lung
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