GLS2 Lysate – Tissue Lysate

Name: GLS2 Lysate; Tissue Lysate; MyBioSource
Brand: MyBioSource
SKU: MBS8412341
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8412341

Human GLS2 Protein Lysate 20ug is provided as a Lyophilized powder.This is a Recombinant Protein Lysate produced in HEK293T cells. This protein lysate can be reconsituted using SDS Sample Buffer. More details

$605 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GLS2, Lysate

Full Product Name

Human GLS2 Protein Lysate

Product Gene Name

GLS2 lysate

Product Synonym Names

GLS2; GA; GLS; hLGA; LGA

Host

Human

Form/Format

Lyophilized

Preparation and Storage

Store at -20 degree C
Once reconsituted, aliquot and store any remaining material at-20 degree C to avoid repeated freeze-thaw cycles.

Molecular Weight

Predicted: 36; 55; 62; 66 kDa

Observed: 55; 62 kDa

OMIM

606365

3D Structure

ModBase 3D Structure for Q9UI32

Other Notes

Small volumes of GLS2 lysate vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLS2 purchase

MBS8412341 is a lysate targeting GLS2. Also known as Human GLS2 Protein Lysate. Host: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for GLS2. It may not necessarily be applicable to this product.

NCBI GI #

20336214

NCBI GeneID

27165

NCBI Accession #

NP_037399

UniProt Primary Accession #

Q9UI32

UniProt Secondary Accession #

Q8IX91; Q9NYY2; Q9UI31; B7Z8Q9

UniProt Related Accession #

Q9UI32

GenBank Nucleotide #

NM_013267

NCBI Official Full Name

glutaminase liver isoform, mitochondrial isoform 1

NCBI Official Synonym Full Names

glutaminase 2 (liver, mitochondrial)

NCBI Official Symbol

GLS2

NCBI Official Synonym Symbols

GA; GLS; LGA; hLGA

UniProt Protein Name

Glutaminase liver isoform, mitochondrial

UniProt Synonym Protein Names

L-glutaminase; L-glutamine amidohydrolase

Protein Family

Glucosidase

UniProt Gene Name

GLS2

UniProt Synonym Gene Names

GA; GLS

UniProt Entry Name

GLSL_HUMAN

NCBI Protein Information

glutaminase liver isoform, mitochondrial; glutaminase I; breast cell glutaminase; L-glutamine amidohydrolase; phosphate-activated glutaminase; phosphate-dependent glutaminase

NCBI Summary for GLS2

The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

UniProt Comments for GLS2

GLS2: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. Belongs to the glutaminase family.

Protein type: Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Energy Metabolism - nitrogen; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Hydrolase

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: protein binding; glutaminase activity

Biological Process: amino acid metabolic process; regulation of apoptosis; synaptic transmission; glutamate secretion; neurotransmitter secretion; glutamine metabolic process; amino acid biosynthetic process

Research Articles on GLS2

1. Silencing GLS or overexpressing GLS2 induces growth inhibition in glioma cell lines.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GLS2 lysate

Reference Product	PubMed Publications
CPS1 lysate	>2 publications with GLS2 and CPS1
GLUL lysate	>1 publications with GLS2 and GLUL

Pathways associated with GLS2 lysate

Products by Pathway	Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies	Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Central Carbon Metabolism In Cancer Pathway antibodies	Central Carbon Metabolism In Cancer Pathway Diagram
Central Carbon Metabolism In Cancer Pathway antibodies	Central Carbon Metabolism In Cancer Pathway Diagram
D-Glutamine And D-glutamate Metabolism Pathway antibodies	D-Glutamine And D-glutamate Metabolism Pathway Diagram
D-Glutamine And D-glutamate Metabolism Pathway antibodies	D-Glutamine And D-glutamate Metabolism Pathway Diagram
GABAergic Synapse Pathway antibodies	GABAergic Synapse Pathway Diagram

Diseases associated with GLS2 lysate

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>4 publications with GLS2 and Liver Diseases
Brain Diseases Antibodies	>2 publications with GLS2 and Brain Diseases
Nervous System Diseases Antibodies	>2 publications with GLS2 and Nervous System Diseases
Lung Neoplasms Antibodies	>2 publications with GLS2 and Lung Neoplasms
Liver Neoplasms Antibodies	>2 publications with GLS2 and Liver Neoplasms
Seizures Antibodies	>1 publications with GLS2 and Seizures
Mental Disorders Antibodies	>1 publications with GLS2 and Mental Disorders
Kidney Diseases Antibodies	>1 publications with GLS2 and Kidney Diseases
Drug-Related Side Effects and Adverse Reactions Antibodies	>1 publications with GLS2 and Drug-Related Side Effects and Adverse Reactions
Carcinoma, Hepatocellular Antibodies	>1 publications with GLS2 and Carcinoma, Hepatocellular

Organs/Tissues associated with GLS2 lysate

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>9 publications with GLS2 and Liver
Brain Antibodies	>9 publications with GLS2 and Brain
Kidney Antibodies	>4 publications with GLS2 and Kidney
Lung Antibodies	>2 publications with GLS2 and Lung
Thyroid Antibodies	>1 publications with GLS2 and Thyroid
Skin Antibodies	>1 publications with GLS2 and Skin