GRP Lysate – Tissue Lysate

Name: GRP Lysate; Tissue Lysate; MyBioSource
Brand: MyBioSource
SKU: MBS8412613
Price: 390 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8412613

Human GRP Protein Lysate 20ug is provided as a Lyophilized powder.This is a Recombinant Protein Lysate produced in HEK293T cells. This protein lysate can be reconsituted using SDS Sample Buffer. More details

$390 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRP, Lysate

Full Product Name

Human GRP Protein Lysate

Product Gene Name

GRP lysate

Product Synonym Names

GRP; BN; GRP-10; preproGRP; proGRP

Host

Human

Form/Format

Lyophilized

Preparation and Storage

Store at -20 degree C
Once reconsituted, aliquot and store any remaining material at-20 degree C to avoid repeated freeze-thaw cycles.

Molecular Weight

16,213 Da

Chromosome Location

Chromosome: 18; NC_000018.9 (56887400..56898003). Location: 18q21.1-q21.32

OMIM

137260

3D Structure

ModBase 3D Structure for P07492

Other Notes

Small volumes of GRP lysate vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRP purchase

MBS8412613 is a lysate targeting GRP. Also known as Human GRP Protein Lysate. Host: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for GRP. It may not necessarily be applicable to this product.

NCBI GI #

31542860

NCBI GeneID

2922

NCBI Accession #

NP_002082

UniProt Primary Accession #

P07492

UniProt Secondary Accession #

P07491; P81553; Q14454; Q53YA0; Q9BSY7

UniProt Related Accession #

P07492

GenBank Nucleotide #

NM_002091

NCBI Official Full Name

gastrin-releasing peptide isoform 1 preproprotein

NCBI Official Synonym Full Names

gastrin-releasing peptide

NCBI Official Symbol

GRP

NCBI Official Synonym Symbols

BN; GRP-10; proGRP; preproGRP

UniProt Protein Name

Gastrin-releasing peptide

UniProt Synonym Protein Names

GRP-10

Protein Family

Beta-1,3-glucan-binding protein

UniProt Gene Name

GRP

UniProt Synonym Gene Names

GRP

UniProt Entry Name

GRP_HUMAN

NCBI Protein Information

gastrin-releasing peptide; bombesin; prepro-GRP; neuromedin C; pre-progastrin releasing peptide

NCBI Summary for GRP

This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for GRP

GRP: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear. Belongs to the bombesin/neuromedin-B/ranatensin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 18q21.1-q21.32

Cellular Component: extracellular space; extracellular region

Molecular Function: neuropeptide hormone activity; receptor binding

Biological Process: neuropeptide signaling pathway; signal transduction

Research Articles on GRP

1. inhibits the process of autophagy in vascular endothelial cells, thereby increasing endothelial cell proliferation and tubule formation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRP lysate

Reference Product	PubMed Publications
GRPR lysate	>133 publications with GRP and GRPR
CCK lysate	>107 publications with GRP and CCK
NMBR lysate	>23 publications with GRP and NMBR
NTS lysate	>4 publications with GRP and NTS

Pathways associated with GRP lysate

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Incretin Synthesis, Secretion, And Inactivation Pathway antibodies	Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Peptide Hormone Metabolism Pathway antibodies	Peptide Hormone Metabolism Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with GRP lysate

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>227 publications with GRP and Lung Neoplasms
Adenocarcinoma Antibodies	>146 publications with GRP and Adenocarcinoma
Inflammation Antibodies	>107 publications with GRP and Inflammation
Pain Antibodies	>71 publications with GRP and Pain
Skin Diseases Antibodies	>68 publications with GRP and Skin Diseases
Liver Diseases Antibodies	>62 publications with GRP and Liver Diseases
Necrosis Antibodies	>53 publications with GRP and Necrosis
Kidney Diseases Antibodies	>52 publications with GRP and Kidney Diseases
Fibrosis Antibodies	>50 publications with GRP and Fibrosis
Head and Neck Neoplasms Antibodies	>37 publications with GRP and Head and Neck Neoplasms

Organs/Tissues associated with GRP lysate

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>399 publications with GRP and Brain
Lung Antibodies	>394 publications with GRP and Lung
Pancreas Antibodies	>222 publications with GRP and Pancreas
Prostate Antibodies	>177 publications with GRP and Prostate
Uterus Antibodies	>38 publications with GRP and Uterus
Eye Antibodies	>35 publications with GRP and Eye
Testis Antibodies	>9 publications with GRP and Testis
Parathyroid Antibodies	>5 publications with GRP and Parathyroid
Pineal Gland Antibodies	>1 publications with GRP and Pineal Gland