ISPD Lysate – Tissue Lysate

Name: ISPD Lysate; Tissue Lysate; MyBioSource
Brand: MyBioSource
SKU: MBS8413724
Price: 390 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8413724

Human ISPD Protein Lysate 20ug is provided as a Lyophilized powder.This is a Recombinant Protein Lysate produced in HEK293T cells. This protein lysate can be reconsituted using SDS Sample Buffer. More details

$390 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ISPD, Lysate

Full Product Name

Human ISPD Protein Lysate

Product Gene Name

ISPD lysate

Product Synonym Names

ISPD; hCG_1745121; MDDGA7; MDDGC7; Nip; hISPD

Host

Human

Form/Format

Lyophilized

Preparation and Storage

Store at -20 degree C
Once reconsituted, aliquot and store any remaining material at-20 degree C to avoid repeated freeze-thaw cycles.

Molecular Weight

44kDa

OMIM

614631

3D Structure

ModBase 3D Structure for A4D126

Other Notes

Small volumes of ISPD lysate vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ISPD purchase

MBS8413724 is a lysate targeting ISPD. Also known as Human ISPD Protein Lysate. Host: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for ISPD. It may not necessarily be applicable to this product.

NCBI GI #

157671913

NCBI GeneID

729920

NCBI Accession #

NP_001094887

UniProt Primary Accession #

A4D126

UniProt Related Accession #

A4D126

GenBank Nucleotide #

NM_001101417

NCBI Official Full Name

D-ribitol-5-phosphate cytidylyltransferase isoform b

NCBI Official Synonym Full Names

CDP-L-ribitol pyrophosphorylase A

NCBI Official Symbol

CRPPA

NCBI Official Synonym Symbols

Nip; ISPD; hISPD; MDDGA7; MDDGC7; LGMDR20

UniProt Protein Name

D-ribitol-5-phosphate cytidylyltransferase

UniProt Synonym Protein Names

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; Isoprenoid synthase domain-containing protein

Protein Family

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

UniProt Gene Name

ISPD

UniProt Synonym Gene Names

hISPD

NCBI Protein Information

D-ribitol-5-phosphate cytidylyltransferase

NCBI Summary for ISPD

This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

UniProt Comments for ISPD

Cytidylyltransferase required for protein O-linked mannosylation (PubMed:26687144, PubMed:27130732, PubMed:27601598, PubMed:22522420, PubMed:22522421). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:26687144, PubMed:27130732). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:26687144, PubMed:27130732). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (PubMed:26687144). Not Involved in dolichol production (PubMed:26687144).

Research Articles on ISPD

1. ISPD and FKTN are essential for the incorporation of ribitol into alpha-dystroglycan.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ISPD lysate

Reference Product	PubMed Publications
IPP lysate	>4 publications with ISPD and IPP

Diseases associated with ISPD lysate

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>9 publications with ISPD and Kidney Diseases
Muscular Diseases Antibodies	>7 publications with ISPD and Muscular Diseases
Renal Insufficiency Antibodies	>6 publications with ISPD and Renal Insufficiency
Congenital Abnormalities Antibodies	>6 publications with ISPD and Congenital Abnormalities
Walker-Warburg Syndrome Antibodies	>6 publications with ISPD and Walker-Warburg Syndrome
Nervous System Malformations Antibodies	>5 publications with ISPD and Nervous System Malformations
Neuromuscular Diseases Antibodies	>4 publications with ISPD and Neuromuscular Diseases
Eye Abnormalities Antibodies	>3 publications with ISPD and Eye Abnormalities
Ocular Motility Disorders Antibodies	>2 publications with ISPD and Ocular Motility Disorders
Hydrocephalus Antibodies	>2 publications with ISPD and Hydrocephalus

Organs/Tissues associated with ISPD lysate

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with ISPD and Brain
Muscle Antibodies	>7 publications with ISPD and Muscle
Blood Antibodies	>7 publications with ISPD and Blood