NTMT1 Lysate – Tissue Lysate

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

METTL11A: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. Belongs to the methyltransferase superfamily. NTM1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.244; Methyltransferase; Methyltransferase, protein N-term

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: histone methyltransferase activity; protein methyltransferase activity

Biological Process: chromosome segregation; histone methylation; N-terminal peptidyl-alanine methylation; N-terminal peptidyl-glycine methylation; N-terminal peptidyl-proline di-methylation; spindle organization and biogenesis