DSP ELISA Kit for Monkey

Name: Monkey DSP ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS2500140
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2500140

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Monkey DSP concentrations in serum, plasma and other biological fluids.Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Product Name

DSP, ELISA Kit

Full Product Name

Monkey DSP (Desmoplakin) ELISA Kit

Product Gene Name

DSP elisa kit

Species Reactivity

Monkey

Assay Type

Sandwich

Samples

Serum, Plasma, Biological Fluids

Detection Range

0.313-20ng/mL

Sensitivity

Min: 0.188ng/mL; Max: 20ng/mL

Specificity

This kit recognizes natural and recombinant Monkey DSP. No significant cross-reactivity or interference between Monkey DSP and analogues was observed.

Preparation and Storage

Store at 4 degree C.

Molecular Weight

278,916 Da

OMIM

125647

3D Structure

ModBase 3D Structure for P15924

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DSP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DSP purchase

MBS2500140 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the DSP, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DSP. The ELISA analytical biochemical technique of the MBS2500140 kit is based on DSP antibody-DSP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DSP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DSP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for DSP. It may not necessarily be applicable to this product.

NCBI GI #

58530840

NCBI GeneID

1832

NCBI Accession #

NP_004406.2

UniProt Primary Accession #

P15924

UniProt Secondary Accession #

O75993; Q14189; Q9UHN4; B2RTT2; D7RX09

UniProt Related Accession #

P15924

GenBank Nucleotide #

NM_004415.2

NCBI Official Full Name

desmoplakin isoform I

NCBI Official Synonym Full Names

desmoplakin

NCBI Official Symbol

DSP

NCBI Official Synonym Symbols

DP; DPI; DPII; DCWHKTA

UniProt Protein Name

Desmoplakin

UniProt Synonym Protein Names

250/210 kDa paraneoplastic pemphigus antigen

Protein Family

Desmoplakin

UniProt Gene Name

DSP

UniProt Synonym Gene Names

UniProt Entry Name

DESP_HUMAN

NCBI Protein Information

desmoplakin; 250/210 kDa paraneoplastic pemphigus antigen; desmoplakin I; desmoplakin II

NCBI Summary for DSP

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]

UniProt Comments for DSP

Desmoplakin: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Cytoskeletal

Chromosomal Location of Human Ortholog: 6p24

Cellular Component: desmosome; mitochondrion; basolateral plasma membrane; plasma membrane; intermediate filament; cornified envelope; fascia adherens; nucleus

Molecular Function: protein binding, bridging; protein binding; protein kinase C binding; structural constituent of cytoskeleton; cell adhesion molecule binding; structural molecule activity

Biological Process: keratinocyte differentiation; cell-cell adhesion; epidermis development; wound healing; apoptosis; intermediate filament organization; peptide cross-linking; cell structure disassembly during apoptosis

Disease: Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma; Arrhythmogenic Right Ventricular Dysplasia, Familial, 8; Keratosis Palmoplantaris Striata Ii; Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis; Skin Fragility-woolly Hair Syndrome; Epidermolysis Bullosa, Lethal Acantholytic

Research Articles on DSP

1. a subset of arrhythmogenic cardiomyopathy mutations, in addition to a mutation associated with skin fragility/woolly hair syndrome, impair gap junction localization and function by misregulating DP-EB1 interactions and altering microtubule dynamics.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DSP elisa kit

Reference Product	PubMed Publications
PKP2 elisa kit	>39 publications with DSP and PKP2
JUP elisa kit	>39 publications with DSP and JUP
DSC1 elisa kit	>8 publications with DSP and DSC1
PKP1 elisa kit	>8 publications with DSP and PKP1
PKP4 elisa kit	>5 publications with DSP and PKP4
CDH5 elisa kit	>1 publications with DSP and CDH5
PKP3 elisa kit	>1 publications with DSP and PKP3

Pathways associated with DSP elisa kit

Products by Pathway	Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies	Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
Apoptotic Cleavage Of Cellular Proteins Pathway antibodies	Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
Apoptotic Execution Phase Pathway antibodies	Apoptotic Execution Phase Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Programmed Cell Death Pathway antibodies	Programmed Cell Death Pathway Diagram

Diseases associated with DSP elisa kit

Disease Name	Pubmed Publications
Poisoning Antibodies	>244 publications with DSP and Poisoning
Pain Antibodies	>117 publications with DSP and Pain
Heart Diseases Antibodies	>111 publications with DSP and Heart Diseases
Brain Diseases Antibodies	>91 publications with DSP and Brain Diseases
Disease Models, Animal Antibodies	>62 publications with DSP and Disease Models, Animal
Heart Defects, Congenital Antibodies	>48 publications with DSP and Heart Defects, Congenital
Nerve Degeneration Antibodies	>32 publications with DSP and Nerve Degeneration
Inflammation Antibodies	>30 publications with DSP and Inflammation
Necrosis Antibodies	>29 publications with DSP and Necrosis
Liver Diseases Antibodies	>24 publications with DSP and Liver Diseases

Organs/Tissues associated with DSP elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>586 publications with DSP and Brain
Heart Antibodies	>195 publications with DSP and Heart
Mouth Antibodies	>194 publications with DSP and Mouth
Skin Antibodies	>146 publications with DSP and Skin
Muscle Antibodies	>136 publications with DSP and Muscle
Bone Antibodies	>127 publications with DSP and Bone
Testis Antibodies	>99 publications with DSP and Testis
Liver Antibodies	>73 publications with DSP and Liver
Lung Antibodies	>70 publications with DSP and Lung
Kidney Antibodies	>53 publications with DSP and Kidney