ATP2B4 Antibody – Mouse Monoclonal

PMCA4: a plasma membrane calcium pump. A magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Eight splice-variant isoforms have been described.

Protein type: Channel, calcium; EC 3.6.3.8; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: basolateral plasma membrane; caveola; integral component of plasma membrane; intracellular membrane-bound organelle; membrane; neuron projection; plasma membrane; protein complex; T-tubule; Z disc

Molecular Function: ATP binding; calcium-transporting ATPase activity; calmodulin binding; metal ion binding; nitric-oxide synthase binding; nitric-oxide synthase inhibitor activity; PDZ domain binding; protein binding; protein kinase binding; protein phosphatase 2B binding; sodium channel regulator activity

Biological Process: calcium ion export; calcium ion import across plasma membrane; cellular calcium ion homeostasis; cellular response to epinephrine stimulus; hippocampus development; negative regulation of adrenergic receptor signaling pathway involved in heart process; negative regulation of arginine catabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric oxide mediated signal transduction; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-cysteine S-nitrosylation; negative regulation of the force of heart contraction; neural retina development; positive regulation of cAMP-dependent protein kinase activity; positive regulation of peptidyl-serine phosphorylation; regulation of cell cycle G1/S phase transition; regulation of sodium ion transmembrane transport; regulation of transcription from RNA polymerase II promoter; response to hydrostatic pressure; sperm motility; spermatogenesis