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CD23 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS210801

Mouse anti Human CD23 antibody, clone D3.6 recognizes CD23, a 45kDa cell surface glycoprotein that acts as a low affinity receptor for IgE. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also… More details

$510 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD23, Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN CD23:FITC
Product Gene Name
anti-CD23 antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
D3.6
Host
Mouse
Form/Format
FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
Concentration
IgG concentration 0.1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
36,469 Da
OMIM
151445
3D Structure
ModBase 3D Structure for P06734
Perservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen
Immunoprecipitated CD23 antigen from purified plasma membranes from EBV-transformed human lymphoblastoid B cell lines
Buffer Solution||Phosphate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-CD23 antibody
Flow cytometry (FC/FACS)
Application Notes for anti-CD23 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Maximum Dilution: Neat

Testing Data of anti-CD23 antibody

Staining of human peripheral blood lymphocytes with Mouse anti Human CD23:Alexa Fluor 647 (MBS212398A647)
Mouse Anti-CD23 Monoclonal Antibody – Cat# MBS210801

Testing Data of anti-CD23 antibody

Staining of human peripheral blood lymphocytes with Mouse anti Human CD23:FITC
Mouse Anti-CD23 Monoclonal Antibody, Testing Data – Cat# MBS210801

Testing Data of anti-CD23 antibody

Staining of human peripheral blood lymphocytes probed with Mouse anti Human CD23:RPE (MBS213691)
Mouse Anti-CD23 Monoclonal Antibody, Testing Data – Cat# MBS210801

Other Notes

Small volumes of anti-CD23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD23 purchase

MBS210801 is an antibody targeting CD23. Also known as MOUSE ANTI HUMAN CD23:FITC. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD23. It may not necessarily be applicable to this product.

NCBI GI #
334085205
NCBI GeneID
2208
NCBI Accession #
NP_001193948.2
UniProt Primary Accession #
P06734
UniProt Related Accession #
P06734
GenBank Nucleotide #
NM_001207019.2
NCBI Official Full Name
low affinity immunoglobulin epsilon Fc receptor isoform b
NCBI Official Synonym Full Names
Fc fragment of IgE, low affinity II, receptor for (CD23)
NCBI Official Symbol
FCER2
NCBI Official Synonym Symbols
CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2
UniProt Protein Name
Low affinity immunoglobulin epsilon Fc receptor
UniProt Synonym Protein Names
BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD_antigen: CD23Cleaved into the following 2 chains:Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form
Protein Family
Low affinity immunoglobulin epsilon Fc receptor
UniProt Gene Name
FCER2
UniProt Synonym Gene Names
CD23A; CLEC4J; FCE2; IGEBF
UniProt Entry Name
FCER2_HUMAN
NCBI Protein Information
low affinity immunoglobulin epsilon Fc receptor; C-type lectin domain family 4, member J; CD23 antigen; fc-epsilon-RII; immunoglobulin E-binding factor; lymphocyte IgE receptor

NCBI Summary for CD23

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
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UniProt Comments for CD23

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Research Articles on CD23

1. Crystal structure of the CD23-Fc3-4 complex with different molecular-packing constraints.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD23 antibody

 Products by Pathway  Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 NOTCH2 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH2 Intracellular Domain Regulates Transcription Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By NOTCH Pathway antibodies  Signaling By NOTCH Pathway Diagram
 Signaling By NOTCH2 Pathway antibodies  Signaling By NOTCH2 Pathway Diagram

Diseases associated with anti-CD23 antibody

 Disease Name  Pubmed Publications
 Asthma Antibodies  >17 publications with CD23 and Asthma
 Lung Diseases Antibodies  >15 publications with CD23 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >14 publications with CD23 and Respiratory Hypersensitivity
 Hypersensitivity Antibodies  >14 publications with CD23 and Hypersensitivity
 Hypersensitivity, Immediate Antibodies  >14 publications with CD23 and Hypersensitivity, Immediate
 Inflammation Antibodies  >2 publications with CD23 and Inflammation
 Carcinoma Antibodies  >1 publications with CD23 and Carcinoma
 Intestinal Diseases Antibodies  >1 publications with CD23 and Intestinal Diseases
 Hyperplasia Antibodies  >1 publications with CD23 and Hyperplasia
 Bronchial Hyperreactivity Antibodies  >1 publications with CD23 and Bronchial Hyperreactivity

Organs/Tissues associated with anti-CD23 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with CD23 and Blood
 Lymph Node Antibodies  >1 publications with CD23 and Lymph Node
 Spleen Antibodies  >1 publications with CD23 and Spleen
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