• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CLDN4 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6168544

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in… More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CLDN4, Monoclonal Antibody
Full Product Name
CLDN4 (Claudin 4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R) (APC)
Product Gene Name
anti-CLDN4 antibody
Product Synonym Names
Claudin 4; CPE-R; CPER; CPETR; CPETR1; WBSCR8; hCPE-R
Clonality
Monoclonal
Isotype
IgG3,k
Clone Number
4A11
Host
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified
Specificity
Recognizes CLDN4.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
23 kDa
OMIM
602909
3D Structure
ModBase 3D Structure for O14493
Immunogen
CLDN4 (NP_001296, 29aa-78aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
MWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQ
Conjugate
APC

Product Categories/Family for anti-CLDN4 antibody

Antibodies; Claudin
Applications Tested/Suitable for anti-CLDN4 antibody
Immunoprecipitation (IP)
Application Notes for anti-CLDN4 antibody
Applications are based on unconjugated antibody.

Testing Data of anti-CLDN4 antibody

Detection limit for recombinant GST tagged CLDN4 is approximately 1ng/ml as a capture antibody.
Mouse Anti-CLDN4 Monoclonal Antibody – Cat# MBS6168544

Immunoprecipitation (IP) of anti-CLDN4 antibody

Immunoprecipitation of CLDN4 transfected lysate using anti-CLDN4 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with CLDN4 MaxPab mouse polyclonal antibody.
Mouse Anti-CLDN4 Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS6168544

Other Notes

Small volumes of anti-CLDN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLDN4 purchase

MBS6168544 is an antibody targeting CLDN4. Also known as CLDN4 (Claudin 4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R) (APC). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CLDN4. It may not necessarily be applicable to this product.

NCBI GI #
4502877
NCBI GeneID
1364
NCBI Accession #
NP_001296
UniProt Primary Accession #
O14493
UniProt Related Accession #
O14493
GenBank Nucleotide #
NM_001305.4
NCBI Official Full Name
claudin-4
NCBI Official Synonym Full Names
claudin 4
NCBI Official Symbol
CLDN4
NCBI Official Synonym Symbols
CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R
UniProt Protein Name
Claudin-4
UniProt Synonym Protein Names
Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein
Protein Family
Claudin
UniProt Gene Name
CLDN4
UniProt Synonym Gene Names
CPER; CPETR1; WBSCR8; CPE-R
UniProt Entry Name
CLD4_HUMAN
NCBI Protein Information
claudin-4; CPE-receptor; Clostridium perfringens enterotoxin receptor 1; Williams-Beuren syndrome chromosomal region 8 protein

NCBI Summary for CLDN4

The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
Show more

UniProt Comments for CLDN4

Claudin-4: Plays a major role in tight junction-specific obliteration of the intercellular space. CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family.

Protein type: Membrane protein, multi-pass; Cytoskeletal; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: tight junction; apicolateral plasma membrane; integral to plasma membrane; apical plasma membrane; basal plasma membrane; plasma membrane; lateral plasma membrane

Molecular Function: identical protein binding; transmembrane receptor activity; structural molecule activity

Biological Process: female pregnancy; response to progesterone stimulus; signal transduction; calcium-independent cell-cell adhesion
Show more

Research Articles on CLDN4

1. The present study demonstrates that high expression of claudins 1, 4, 5 and down-regulation of claudin-7 are positive prognostic markers and are associated with good outcome and increased survival rates.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLDN4 antibody

 Reference Product  PubMed Publications
 TJP1 antibody  >45 publications with CLDN4 and TJP1
 WNK4 antibody  >1 publications with CLDN4 and WNK4
 EPHA2 antibody  >1 publications with CLDN4 and EPHA2

Pathways associated with anti-CLDN4 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram

Diseases associated with anti-CLDN4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >154 publications with CLDN4 and Neoplasms
 Adenocarcinoma Antibodies  >58 publications with CLDN4 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >36 publications with CLDN4 and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >32 publications with CLDN4 and Breast Neoplasms
 Pancreatic Neoplasms Antibodies  >24 publications with CLDN4 and Pancreatic Neoplasms
 Inflammation Antibodies  >20 publications with CLDN4 and Inflammation
 Neoplasm Invasiveness Antibodies  >20 publications with CLDN4 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >18 publications with CLDN4 and Neoplasm Metastasis
 Necrosis Antibodies  >17 publications with CLDN4 and Necrosis
 Uterine Neoplasms Antibodies  >14 publications with CLDN4 and Uterine Neoplasms

Organs/Tissues associated with anti-CLDN4 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >47 publications with CLDN4 and Intestine
 Cervix Antibodies  >3 publications with CLDN4 and Cervix
 Placenta Antibodies  >3 publications with CLDN4 and Placenta
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000