EphA8 Antibody – Mouse Monoclonal

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]

EphA8: a receptor tyrosine kinase of the Eph family. A receptor for members of the ephrin-A family: ephrin A2, A3 and A5. Plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Contains 1 sterile alpha motif (SAM) domain and 2 fibronectin type III domains.

Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; Protein kinase, TK; TK group; Eph family

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: neuron projection; integral to plasma membrane; early endosome membrane; plasma membrane

Molecular Function: GPI-linked ephrin receptor activity; ATP binding

Biological Process: regulation of cell adhesion; substrate-bound cell migration; axon guidance; regulation of cell adhesion mediated by integrin; peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; protein amino acid autophosphorylation; ephrin receptor signaling pathway; positive regulation of phosphoinositide 3-kinase activity; cell adhesion; neurite development; neuron remodeling