FOXA2 Antibody – Mouse Monoclonal

FOXA2: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Binds DNA as a monomer. Binds TLE1. Interacts with FOXA1 and FOXA3. Interacts with PRKDC. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 20p11

Cellular Component: cytoplasm; nucleus

Molecular Function: protein domain specific binding; DNA binding; transcription factor binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; adult locomotory behavior; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter by glucose; cell fate specification; negative regulation of glucokinase activity; cell differentiation in hindbrain; ectoderm formation; regulation of steroid metabolic process; positive regulation of smoothened signaling pathway; neuron fate specification; positive regulation of transcription from RNA polymerase II promoter by glucose; dorsoventral neural tube patterning; in utero embryonic development; negative regulation of transcription factor activity; chromatin modification; somite rostral/caudal axis specification; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; positive regulation of embryonic development; regulation of blood coagulation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; cell development