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NME4 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS834513

MBS834513 is an antibody targeting NME4. Also known as NME4 antibody. Host: Mouse. Mouse monoclonal NME4 antibody More details

$1615 / 0.1 mL +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NME4, Monoclonal Antibody
Full Product Name
NME4 antibody
Product Gene Name
anti-NME4 antibody
Product Synonym Names
Monoclonal NME4; Anti-NME4; Non-Metastatic Cells 4 Protein Expressed In; NM23H4; nm23-H4; NME4; NME 4; NME-4
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
2G1
Host
Mouse
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purity/Purification
NME4 antibody was purified by affinity chromatography.
Concentration
500 ug-1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
12,979 Da
OMIM
601818
3D Structure
ModBase 3D Structure for O00746
Cross-Reactivity
Human
Immunogen
NME4 antibody was raised in mouse using a full length recombinant protein of human NME4 (NP_005000) produced in HEK293T cells, as the immunogen.

Product Categories/Family for anti-NME4 antibody

Proteases; Inhibitors; & Enzymes
Applications Tested/Suitable for anti-NME4 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-NME4 antibody
FC: 1:100
IF: 1:100
IHC: 1:50
WB: 1:2000

Flow Cytometry (FC/FACS) of anti-NME4 antibody

Flow Cytometric analysis of HEK293T cells transfected with either recombinant NME4 protein (red) or empty vector (blue) stained using NME4 antibody
Mouse Anti-NME4 Monoclonal Antibody – Cat# MBS834513

Western Blot (WB) of anti-NME4 antibody

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant NME4 protein (Right) or empty vector (Left) detected with NME4 antibody
Mouse Anti-NME4 Monoclonal Antibody, Western Blot (WB) – Cat# MBS834513

Immunohistochemistry (IHC) of anti-NME4 antibody

Immunohistochemical analysis of NME4 protein in paraffin embedded Human liver tissue using NME4 antibody
Mouse Anti-NME4 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS834513

Immunofluorescence (IF) of anti-NME4 antibody

Immunofluorescent staining of COS7 cells transiently transfected with recombinant NME4 protein using NME4 antibody
Mouse Anti-NME4 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS834513

Other Notes

Small volumes of anti-NME4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NME4. It may not necessarily be applicable to this product.

NCBI GI #
4826862
NCBI GeneID
4833
NCBI Accession #
NP_005000
UniProt Primary Accession #
O00746
UniProt Secondary Accession #
Q5U0M9; A2IDD0
UniProt Related Accession #
O00746
GenBank Nucleotide #
NM_005009.2
NCBI Official Full Name
nucleoside diphosphate kinase, mitochondrial isoform a
NCBI Official Synonym Full Names
NME/NM23 nucleoside diphosphate kinase 4
NCBI Official Symbol
NME4
NCBI Official Synonym Symbols
NDPK-D; NM23H4; nm23-H4
UniProt Protein Name
Nucleoside diphosphate kinase, mitochondrial
UniProt Synonym Protein Names
Nucleoside diphosphate kinase D; NDPKD; nm23-H4
UniProt Gene Name
NME4
UniProt Synonym Gene Names
NM23D; NDK; NDP kinase, mitochondrial; NDPKD
UniProt Entry Name
NDKM_HUMAN
NCBI Protein Information
nucleoside diphosphate kinase, mitochondrial

NCBI Summary for NME4

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]
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UniProt Comments for NME4

NME4: Major role in the synthesis of nucleoside triphosphates other than ATP. Belongs to the NDK family.

Protein type: Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; EC 2.7.4.6; Mitochondrial; Kinase, other; Kinase, nucleoside diphosphate; Other group; NDK family

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; cytosol

Molecular Function: protein binding; metal ion binding; protein complex binding; nucleoside diphosphate kinase activity; ATP binding

Biological Process: regulation of apoptosis; GTP biosynthetic process; CTP biosynthetic process; pyrimidine nucleotide metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; UTP biosynthetic process; nucleoside triphosphate biosynthetic process; nucleoside metabolic process; nucleoside diphosphate phosphorylation; purine nucleotide metabolic process
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Research Articles on NME4

1. miR-196 performed it's their function by inhibiting NME4 expression and further activating p-JNK, suppressing TIMP1, and augmenting MMP1/9.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NME4 antibody

 Reference Product  PubMed Publications
 AK4 antibody  >1 publications with NME4 and AK4

Pathways associated with anti-NME4 antibody

 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with anti-NME4 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >2 publications with NME4 and Neoplasm Metastasis
 Cardiomyopathies Antibodies  >1 publications with NME4 and Cardiomyopathies
 Neurobehavioral Manifestations Antibodies  >1 publications with NME4 and Neurobehavioral Manifestations
 Lung Diseases Antibodies  >1 publications with NME4 and Lung Diseases
 Cardiovascular Diseases Antibodies  >1 publications with NME4 and Cardiovascular Diseases
 Anemia Antibodies  >1 publications with NME4 and Anemia
 Breast Neoplasms Antibodies  >1 publications with NME4 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with NME4 and Kidney Diseases
 Inflammation Antibodies  >1 publications with NME4 and Inflammation

Organs/Tissues associated with anti-NME4 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with NME4 and Liver
 Stomach Antibodies  >3 publications with NME4 and Stomach
 Kidney Antibodies  >2 publications with NME4 and Kidney
 Blood Antibodies  >2 publications with NME4 and Blood
 Muscle Antibodies  >2 publications with NME4 and Muscle
 Lymph Node Antibodies  >2 publications with NME4 and Lymph Node
 Heart Antibodies  >2 publications with NME4 and Heart
 Ovary Antibodies  >1 publications with NME4 and Ovary
 Intestine Antibodies  >1 publications with NME4 and Intestine
 Embryonic Tissue Antibodies  >1 publications with NME4 and Embryonic Tissue
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