Activin A Precursor (ACVR1C) Antibody – Mouse Monoclonal

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, TKL; EC 2.7.11.30; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q24.1

Cellular Component: plasma membrane; activin receptor complex

Molecular Function: transforming growth factor beta receptor activity; activin receptor activity, type I; metal ion binding; growth factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: response to dietary excess; sequestering of lipid; apoptotic nuclear changes; response to glucose stimulus; positive regulation of caspase activity; cell differentiation; protein amino acid phosphorylation; response to insulin stimulus; negative regulation of insulin secretion