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CD134 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS666317

Information: Human CD134 (OX40) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the tumor necrosis factor (TNF) receptor family of molecules and may be involved with regulating… More details

$435 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD134, Monoclonal Antibody
Full Product Name
anti-human CD134(OX40)-Purified (with Antibiotics)
Product Gene Name
Product Synonym Names
Monoclonal anti-human CD134 (OX40)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BerAct35
Host
Mouse
Species Reactivity
Human
Form/Format
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate
Purity/Purification
Purified (with Antibiotics)
Concentration
1.0 mg/ml (lot specific)
Preparation and Storage
Store at 2 - 5 degree C. Freeze/Thawing is not recommended.
Product should retain activity for at least 12 months after shipping date when stored as recommended.
Molecular Weight
29,341 Da
OMIM
615593
3D Structure
ModBase 3D Structure for P43489
Performance
Five x 105 cultured human HPB-MLT cells were incubated 45 minutes on ice with 80 mul of anti-CD134 antibody at a concentration of 10 mug/ml. Cells were washed twice and incubated with 2 degree reagent Goat anti-Mouse/FITC, after which they were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 1.10 log10 fluorescent units when compared to a Mouse IgG1 negative control at a similar concentration.
Production
Antibody was Protein A purified from (low FBS containing) tissue culture supernatant. Purity was >95% Immunoglobulin by SDS-PAGE and contains less than 1% Bovine Immunoglobulin.
Buffer
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5 mg/ml Gentamicin Sulfate (as a preservative).
Group Header
anti-human CD134(OX40)
Immunogen
Human HUT 102 T cells
Applications Tested/Suitable for anti-CD134 antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Immunohistochemistry (IHC), FX, FPS

Testing Data of anti-CD134 antibody

Mouse Anti-CD134 Monoclonal Antibody – Cat# MBS666317

Product References and Citations for anti-CD134 antibody

U. Latza et al, Eur J Immunol (1994) 24: 677-683. E. Stuber, et al, (1995) Immunity 2: 507-521. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 464-465. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford (1995) p. 1157-1160.

Other Notes

Small volumes of anti-CD134 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD134 purchase

MBS666317 is an antibody targeting CD134. Also known as anti-human CD134(OX40)-Purified (with Antibiotics). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD134. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CD134 antigen
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 4
NCBI Official Symbol
TNFRSF4
NCBI Official Synonym Symbols
OX40; ACT35; CD134; IMD16; TXGP1L
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 4
UniProt Synonym Protein Names
ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD_antigen: CD134
UniProt Gene Name
TNFRSF4
UniProt Synonym Gene Names
TXGP1L
UniProt Entry Name
TNR4_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 4; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor

NCBI Summary for CD134

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD134

TNFRSF4: Receptor for TNFSF4/OX40L/GP34.

Protein type: Receptor, misc.; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane

Molecular Function: tumor necrosis factor receptor activity

Biological Process: regulation of apoptosis; T cell proliferation; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; inflammatory response

Disease: Immunodeficiency 16
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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