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CD31 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6123934

MBS6123934 is an antibody targeting CD31. Also known as CD31 (EndoCAM, PECA1, Platelet Endothelial Cell Adhesion Molecule 1, GPIIA', PECAM-1) (AP). Reactive in Human. Host: Mouse. More details

$980 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD31, Monoclonal Antibody
Full Product Name
CD31 (EndoCAM, PECA1, Platelet Endothelial Cell Adhesion Molecule 1, GPIIA', PECAM-1) (AP)
Product Gene Name
anti-CD31 antibody
Product Synonym Names
EndoCAM; PECA1; Platelet Endothelial Cell Adhesion Molecule 1; GPIIA'; PECAM-1
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
SPM122
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A/G Affinity Chromatography.
Specificity
Recognizes CD31. Species Crossreactivity: Human, Cynomolgus Monkey and Rabbit. Does not react with rat and procine.
Preparation and Storage
May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing alkaline phosphatase conjugates will result in a substantial loss of activity.
Molecular Weight
82,536 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (62396775..62404856, complement). Location: 17q23.3
OMIM
173445
3D Structure
ModBase 3D Structure for P16284
Immunogen
Membrane preparation of a spleen from a patient with hairy cell leukemia (JC/70A). Cellular Localization: Cell surface and cytoplasm of endothelial cells
Conjugate
AP
Positive Control
Tonsil, Angiosarcoma

Product Categories/Family for anti-CD31 antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-CD31 antibody
ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CD31 antibody
IP: 0.5-1ug/500ug protein lysate
IHC: 0.5-1.0ug/ml for 30 minutes at RT
IF: 0.5-1ug/ml
WB: 0.5-1.0ug/ml
Applications are based on unconjugated antibody.

Immunohistochemistry (IHC) of anti-CD31 antibody

Formalin-paraffin tonsil stained with CD31 MAb (SPM122)
Mouse Anti-CD31 Monoclonal Antibody – Cat# MBS6123934

Product References and Citations for anti-CD31 antibody

1. Gratzinger D et. al. Am J Clin Pathol 131:264-278 (2009).

Other Notes

Small volumes of anti-CD31 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD31. It may not necessarily be applicable to this product.

NCBI GI #
313760624
NCBI GeneID
5175
NCBI Accession #
NP_000433.4
UniProt Primary Accession #
P16284
UniProt Secondary Accession #
Q6LDA9; Q8TBH1; Q96RF5; Q96RF6; Q9NP65; Q9NPB7; Q9NPG9; Q9NQS9; Q9NQT0; Q9NQT1; Q9NQT2
UniProt Related Accession #
P16284
GenBank Nucleotide #
NM_000442.4
NCBI Official Full Name
platelet endothelial cell adhesion molecule
NCBI Official Synonym Full Names
platelet/endothelial cell adhesion molecule 1
NCBI Official Symbol
PECAM1
NCBI Official Synonym Symbols
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
UniProt Protein Name
Platelet endothelial cell adhesion molecule
UniProt Synonym Protein Names
EndoCAM; GPIIA'; PECA1
Protein Family
Platelet endothelial cell adhesion molecule
UniProt Gene Name
PECAM1
UniProt Synonym Gene Names
PECAM-1
UniProt Entry Name
PECA1_HUMAN
NCBI Protein Information
platelet endothelial cell adhesion molecule; CD31 antigen

NCBI Summary for CD31

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
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UniProt Comments for CD31

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; platelet alpha granule membrane; integral to membrane; plasma membrane; cell junction

Molecular Function: protein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; blood coagulation; signal transduction; cell adhesion; leukocyte migration; phagocytosis
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Research Articles on CD31

1. The increased CD105/CD31 and VEGF/CD31 ratios in gingiva confirms an augmented proliferative fraction of the endothelium in gingiva with chronic periodontitis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD31 antibody

 Reference Product  PubMed Publications
 CD38 antibody  >63 publications with CD31 and CD38
 SRC antibody  >58 publications with CD31 and SRC
 CTNNB1 antibody  >42 publications with CD31 and CTNNB1
 PTPN11 antibody  >33 publications with CD31 and PTPN11
 PTPN6 antibody  >17 publications with CD31 and PTPN6
 CSK antibody  >6 publications with CD31 and CSK
 FYN antibody  >5 publications with CD31 and FYN
 ITGB3 antibody  >4 publications with CD31 and ITGB3
 LYN antibody  >3 publications with CD31 and LYN
 JUP antibody  >3 publications with CD31 and JUP

Pathways associated with anti-CD31 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PECAM1 Interactions Pathway antibodies  PECAM1 Interactions Pathway Diagram

Diseases associated with anti-CD31 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1570 publications with CD31 and Neoplasms
 Inflammation Antibodies  >443 publications with CD31 and Inflammation
 Necrosis Antibodies  >373 publications with CD31 and Necrosis
 Neoplasms, Experimental Antibodies  >235 publications with CD31 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >228 publications with CD31 and Neoplasm Metastasis
 Lung Diseases Antibodies  >211 publications with CD31 and Lung Diseases
 Heart Diseases Antibodies  >210 publications with CD31 and Heart Diseases
 Breast Neoplasms Antibodies  >187 publications with CD31 and Breast Neoplasms
 Lung Neoplasms Antibodies  >164 publications with CD31 and Lung Neoplasms
 Liver Diseases Antibodies  >149 publications with CD31 and Liver Diseases

Organs/Tissues associated with anti-CD31 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >3069 publications with CD31 and Vascular
 Blood Antibodies  >2726 publications with CD31 and Blood
 Muscle Antibodies  >607 publications with CD31 and Muscle
 Bone Marrow Antibodies  >397 publications with CD31 and Bone Marrow
 Lung Antibodies  >384 publications with CD31 and Lung
 Heart Antibodies  >313 publications with CD31 and Heart
 Brain Antibodies  >289 publications with CD31 and Brain
 Liver Antibodies  >270 publications with CD31 and Liver
 Umbilical Cord Antibodies  >216 publications with CD31 and Umbilical Cord
 Kidney Antibodies  >215 publications with CD31 and Kidney
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