CD68 Antibody – Rabbit Monoclonal

Macrosialin, also known as CD68 and Gp11, is a single-pass type I membrane protein which belongs to theLAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue-and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Strobl H. et al., 1995, Br J Haematol. 90 (4): 774-82. Ogawa Y. et al., 1995, Pathol Int. 45 (9): 698-701. Sadovnikova E. et al., 2002, Leukemia. 16 (10): 2019-26. Gottfried E. et al., 2008, Scand J Immunol. 67 (5): 453-63. Strojnik T. et al., 2009, Anticancer Res. 29 (8): 3269-79.

Small volumes of anti-CD68 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8105025 is an antibody targeting CD68. Also known as Recombinant Anti-CD68 Antibody, Rabbit Monoclonal. Reactive in Human. Host: Rabbit.