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anti-CDX2 antibody :: Rabbit CDX2 Monoclonal Antibody

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Catalog # MBS4380526
Unit / Price
  0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
  0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $340 +1 FREE 8GB USB
  0.1 mg (Without BSA & Azide at 1mg/ml)  /  $340 +1 FREE 8GB USB
Product Name

CDX2, Monoclonal Antibody

Popular Item
Also Known As

CDX2 (GI Epithelial Marker)

Product Synonym Names
Caudal type homeobox 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
313
3D Structure
ModBase 3D Structure for Q99626
Clonality
Monoclonal
Isotype
IgG
Clone Number
CDX2/2951R
Host
Rabbit
Species Reactivity
Human. Others not known.
Specificity
The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Immunogen
Recombinant fragment (around aa150-249) of human CDX2 protein (exact sequence is proprietary)
Positive Control
HT29 Cells or Colon Carcinoma
Cellular Localization
Nuclear
Chromosome Location
13q12.2
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Other Notes
Small volumes of anti-CDX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDX2 antibody
Recombinant Rabbit Monoclonal Antibody
Applications Tested/Suitable for anti-CDX2 antibody
ELISA (EIA), Immunohistology (Formalin-Fixed)
Application Notes for anti-CDX2 antibody
ELISA: Use Ab at 2-4ug/ml for coating (Order Ab without BSA)
Immunohistology (Formalin-Fixed): 1-2ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-CDX2 antibody
Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CDX2 Rabbit Recombinant Monoclonal Antibody (CDX2/2951R).
anti-CDX2 antibody Immunohistochemistry (IHC) (IHC) image
SDS-Page of anti-CDX2 antibody
SDS-PAGE Analysis Purified CDX2 Rabbit Recombinant Monoclonal Antibody (CDX2/2951R). Confirmation of Purity and Integrity of Antibody.
anti-CDX2 antibody SDS-Page image
Immunohistochemistry (IHC) of anti-CDX2 antibody
Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CDX2 Rabbit Recombinant Monoclonal Antibody (CDX2/2951R).
anti-CDX2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CDX2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40kDa
NCBI Official Full Name
homeobox protein CDX-2 isoform 1
NCBI Official Synonym Full Names
caudal type homeobox 2
NCBI Official Symbol
NCBI Official Synonym Symbols
CDX3; CDX-3; CDX2/AS
  [Similar Products]
NCBI Protein Information
homeobox protein CDX-2
UniProt Protein Name
Homeobox protein CDX-2
UniProt Synonym Protein Names
CDX-3; Caudal-type homeobox protein 2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for CDX2
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
UniProt Comments for CDX2
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Product References and Citations for anti-CDX2 antibody
Silberg, D.G., et al. 2000. Gastroenterology 119: 961-971.; Mallo, G.V., et al. 1998. J. Biol. Chem. 273: 14030-14036.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-CDX2 antibody
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