• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CDX2 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4380526

MBS4380526 is an antibody targeting CDX2. Also known as CDX2 (GI Epithelial Marker). Reactive in Human. Others not known.. Host: Rabbit. Recombinant Rabbit Monoclonal Antibody More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CDX2, Monoclonal Antibody
Full Product Name
CDX2 (GI Epithelial Marker)
Product Gene Name
Product Synonym Names
Caudal type homeobox 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX2
Clonality
Monoclonal
Isotype
IgG
Clone Number
CDX2/2951R
Host
Rabbit
Species Reactivity
Human. Others not known.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Specificity
The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
40kDa
3D Structure
ModBase 3D Structure for Q99626
Immunogen
Recombinant fragment (around aa150-249) of human CDX2 protein (exact sequence is proprietary)
Positive Control
HT29 Cells or Colon Carcinoma
Cellular Localization
Nuclear
Chromosome Location
13q12.2
Applications Tested/Suitable for anti-CDX2 antibody
ELISA (EIA), Immunohistology (Formalin-Fixed)
Application Notes for anti-CDX2 antibody
ELISA: Use Ab at 2-4ug/ml for coating (Order Ab without BSA)
Immunohistology (Formalin-Fixed): 1-2ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-CDX2 antibody

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CDX2 Rabbit Recombinant Monoclonal Antibody (CDX2/2951R).
Rabbit Anti-CDX2 Monoclonal Antibody – Cat# MBS4380526

SDS-Page of anti-CDX2 antibody

SDS-PAGE Analysis Purified CDX2 Rabbit Recombinant Monoclonal Antibody (CDX2/2951R). Confirmation of Purity and Integrity of Antibody.
Rabbit Anti-CDX2 Monoclonal Antibody, SDS-Page – Cat# MBS4380526

Immunohistochemistry (IHC) of anti-CDX2 antibody

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CDX2 Rabbit Recombinant Monoclonal Antibody (CDX2/2951R).
Rabbit Anti-CDX2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4380526

Product References and Citations for anti-CDX2 antibody

Silberg, D.G., et al. 2000. Gastroenterology 119: 961-971.; Mallo, G.V., et al. 1998. J. Biol. Chem. 273: 14030-14036.

Other Notes

Small volumes of anti-CDX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDX2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
homeobox protein CDX-2 isoform 1
NCBI Official Synonym Full Names
caudal type homeobox 2
NCBI Official Symbol
CDX2
NCBI Official Synonym Symbols
CDX3; CDX-3; CDX2/AS
UniProt Protein Name
Homeobox protein CDX-2
UniProt Synonym Protein Names
CDX-3; Caudal-type homeobox protein 2
Protein Family
UniProt Gene Name
CDX2
UniProt Synonym Gene Names
CDX3
NCBI Protein Information
homeobox protein CDX-2

NCBI Summary for CDX2

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
Show more

UniProt Comments for CDX2

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-CDX2 antibody

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000